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Schaechter's Mechanisms of Microbial Disease
Schaechter's Mechanisms of Microbial Disease provides students with a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text is universally praised for "telling the story of a pathogen" in an engaging way, facilitating learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. The table of contents is uniquely organized by microbial class and by organ system, making it equally at home in traditional and systems-based curricula. Case studies with problem-solving questions give students insight into clinical applications of microbiology, which is ideal for problem-based learning.
The Bacteria
The reviews in this volume deal with questions of the mechanisms of pathogenesis and with organisms that have only recently been extensively studied on the molecular level.**The introductory section presents an overview of pathogenesis, emphasizing common elements and genetic mechanisms of regulation and a review on the population genetics of bacterial pathogenesis. The second section deals with the regulation of synthesis of surface components and their role in the colonization of the host and/or of the host immune systems. The third section covers the invasion and intracellular growth of facultative and obligate intracellular parasites. The last section is devoted to studies of the role of bacterial toxic products in pathogenesis.
Principles of Bacterial Pathogenesis
Principles of Bacterial Pathogenesis presents a molecular perspective on a select group of bacterial pathogens by having the leaders of the field present their perspective in a clear and authoritative manner. Each chapter contains a comprehensive review devoted to a single pathogen. Several chapters include work from authors outside the pathogenesis field, providing general perspectives on the evolution, regulation, and secretion of virulence and determinants. - Explains the basic principles of bacterial pathogenesis - Covers diverse aspects integrating regulation, cellular microbiology and evolution of microbial disease of humans - Discusses current strategies for the identification of virulence determinants and the methods used by microbes to deliver virulence factors - Presents authoritative treatises of the major disease microorganisms
Signal Transduction and Bacterial Virulence
In order to survive, bacteria must constantly monitor their structure and physiology. Adaptive behaviours are established by using environmental sensors and response regulators. These communication modules regulate a wide variety of signals including host detection and invasion, cell cycle, metabolite utilization, starvation and many others. The purpose of this volume is to give an overview of the various systems and to introduce recent advances in understanding selected systems of pathogenic bacteria.
Mucosal Immunology
Mucosal Immunology, now in its fourth edition, is the only comprehensive reference covering the basic science and clinical manifestations of mucosal immunology. Most infectious agents enter the body through the various mucous membranes, and many common infections take place in or on mucous membranes, making this subject an area of singular importance in the field of immunology. This book contains new research data, exceptional illustrations, original theory, a new perspective, and excellent organization. It covers immune system topics, such as inductive and effector tissues and cells, and development and physiology of the mucosal barrier; diseases in the digestive system, respiratory tract, and genitourinary tract; and immunodeficiency. - The most comprehensive text on mucosal immunology from internationally recognized experts in the field - Includes exceptional color illustrations, new research data, original theory and information on all mucosal diseases - Contains nine new chapters and an expanded appendix
Microbial Modulation of Host Apoptosis and Pyroptosis
Infectious disease is the result of an interactive relationship between a microbial pathogen and its host. In this interaction both the host and the pathogen attempt to manipulate each other using a complex network to maximize their respective survival probabilities. Programmed host cell death is a direct outcome of host-pathogen interaction and may benefit host or pathogen depending on microbial pathogenesis. Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis...
Trace Metals and Infectious Diseases
Experts explore the influence of trace metals on the pathogenesis of infectious diseases. Many parts of the world in which common infectious diseases are endemic also have the highest prevalence of trace metal deficiencies or rising rates of trace metal pollution. Infectious diseases can increase human susceptibility to adverse effects of metal exposure (at suboptimal or toxic levels), and metal excess or deficiency can increase the incidence or severity of infectious diseases. The co-clustering of major infectious diseases with trace metal deficiency or toxicity has created a complex web of interactions with serious but poorly understood health repercussions, yet has been largely overlooked...
Cholera: The Biography
Cholera is a frightening disease. Victims are wracked by stomach cramps and suffer intense diarrhoea. Death can come within hours. Though now seeming a distant memory in Europe, which suffered several epidemics in the 19th century before John Snow identified the link with water, it is still a serious threat in many parts of the world - Zimbabwe is a recent example. Snow's discovery was one of the great breakthroughs of epidemiology and a wonderful story from the history of science. Later came the discovery of the culprit organism - Cholera vibrio - understanding of its life cycle, and the development of a vaccine. But the problem of cholera has not disappeared. This book tells the story of c...
ADP-ribosylating Toxins and G Proteins
Twenty-eight contributions topics and authors spanning the disciplines of microbiology, biochemistry, molecular biology, and medicine present what is known in an area that has important implications for aspects of biomedical research. Investigations of the mechanisms of action of the ADP-ribosylatin
The Activities of Bacterial Pathogens in Vivo
Pathogenic bacteria have unique biological properties, which enable them to invade a host and cause sickness. The molecular bases of these biological properties are the determinants of pathogenicity, and the research objectives are to recognize them, identify them chemically and relate their structure to function. Most of our present knowledge comes from studies with cultures in vitro . However, there is a rising interest in bacterial behaviour in the infected host and new methods have been developed for studying it. This book describes those methods and shows how they, and a recent surge in conventional studies, are shedding light on the activities of bacterial pathogens in vivo . It discus...
