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Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight
  • Language: en

Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight

  • Type: Book
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  • Published: 2016-08-23
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  • Publisher: Springer

Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dep...

Quorum Sensing and its Biotechnological Applications
  • Language: en
  • Pages: 279

Quorum Sensing and its Biotechnological Applications

  • Type: Book
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  • Published: 2018-08-11
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  • Publisher: Springer

This book delves into the biotechnological applications of Quorum sensing (QS)- a peculiar gene-regulatory process of some microorganisms. Quorum Sensing allows a large bacterial population to work together in a coordinated manner to carry out metabolic activities, which individual bacterium cannot. The different chapters describe how, associating bioremediation process with energy generation is an economical proposal, for reducing pollution and managing biowastes. The book discusses how QS can be exploited for biotechnological applications in generating bioproducts, bioenergy, bioremediation, biosensors, health and agricultural activities. It further highlights how QS is becoming an integral part of synthetic biology for genetic circuits for producing: (i) novel products, (ii) biosensors, (iii) bioactive molecules, etc. The book is divided into different sections for a clear understanding of the applicability of QS in, the Environment, Energy, Agriculture and Health sectors.

Metabolic Engineering for Bioactive Compounds
  • Language: en
  • Pages: 413

Metabolic Engineering for Bioactive Compounds

  • Type: Book
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  • Published: 2017-10-07
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  • Publisher: Springer

This book comprehensively discusses the latest research in the area of metabolic engineering. Metabolic engineering solutions for bioactive compounds are now being derived by means of heterologous gene expression, in a wide range of organisms. The book provides an overview of the model systems being employed for metabolic manipulation to yield bioactive molecules, such as single-cell proteins, antibody generation, metabolites, proteases, chaperones, therapeutic proteins, nanomaterials, polymeric conjugates, dendrimers and nanoassemblies, Escherichia coli, Agrobacterium, Saccharomyces cerevisiae and cell lines, etc. In addition, it shares insights into the scope of these methods in the areas of prevention, diagnosis and treatment of diseases, e.g. immunotherapy for curing various diseases like cancer, allergies, autoimmune diseases, etc.

Biotechnological Applications of Polyhydroxyalkanoates
  • Language: en
  • Pages: 424

Biotechnological Applications of Polyhydroxyalkanoates

  • Type: Book
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  • Published: 2019-01-24
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  • Publisher: Springer

This book presents the latest research on the uses of polyhydroxyalkanoates (PHA), introducing readers to these natural, biodegradable polyesters produced by microorganisms, their functions and applications. The individual chapters discuss the various potentials of these bioplastics, which offer an attractive alternative to non-biodegradable plastics. The book also describes the diverse medical and biomedical applications of PHAs, including their use as drug carriers, memory enhancers, and biocontrol agents, and examines their role in creating a more sustainable economy – which is the need of the hour.

Biotechnological Applications of Quorum Sensing Inhibitors
  • Language: en
  • Pages: 473

Biotechnological Applications of Quorum Sensing Inhibitors

  • Type: Book
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  • Published: 2018-05-30
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  • Publisher: Springer

This book discusses the practical applications of quorum sensing inhibitors for both human and plant health. Quorum sensing inhibitors that disrupt microbial biofilms can be employed to treat bacterial infections. The book describes the various bioactive molecules that can serve as quorum sensing inhibitors to combat deadly bacterial infections, in addition to several synthetic quorum sensing inhibitors. Quorum sensing is the mechanism through which bacteria develop antibiotic resistance. Intended to provide a clearer understanding of the practical applications of quorum sensing inhibitors, the book details how the problem of antibiotic resistance can be countered through the intelligent application of quorum sensing inhibitors.

Microbial Factories
  • Language: en

Microbial Factories

  • Type: Book
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  • Published: 2016-03-03
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  • Publisher: Springer

This book highlights the efforts made by distinguished scientific researchers world-wide to meet two key challenges: i) the limited reserves of polluting fossil fuels, and ii) the ever-increasing amounts of waste being generated. These case studies have brought to the foreground certain innovative biological solutions to real-life problems we now face on a global scale: environmental pollution and its role in deteriorating human health. The book also highlights major advances in microbial metabolisms, which can be used to produce bioenergy, biopolymers, bioactive molecules, enzymes, etc. Around the world, countries like China, Germany, France, Sweden and the US are now implementing major nat...

Microbial Factories
  • Language: en
  • Pages: 360

Microbial Factories

  • Type: Book
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  • Published: 2016-02-16
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  • Publisher: Springer

This book highlights the efforts made by distinguished scientific researchers world-wide to meet two key challenges: i) the limited reserves of polluting fossil fuels, and ii) the ever-increasing amounts of waste being generated. These case studies have brought to the foreground certain innovative biological solutions to real-life problems we now face on a global scale: environmental pollution and its role in deteriorating human health. The book also highlights major advances in microbial metabolisms, which can be used to produce bioenergy, biopolymers, bioactive molecules, enzymes, etc. Around the world, countries like China, Germany, France, Sweden and the US are now implementing major nat...

Microbial Bioprocessing of Agri-food Wastes
  • Language: en
  • Pages: 289

Microbial Bioprocessing of Agri-food Wastes

  • Type: Book
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  • Published: 2023-04-28
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  • Publisher: CRC Press

Enzymes are biological molecules of great relevance. In addition to the fundamental role in metabolic reactions, they have diverse applications in industrial processes in generating products of great commercial utility for the most diverse areas. Thus, industries seek to expand research to select microorganisms capable of producing enzymes according to their commercial objectives. Considering the diversity of the microbiota kingdom, as well as the diversity of mode of action of different classes of enzymes, this is an area that deserves constant investments to elucidate new applications, considering that these biological catalysts have great selectivity and a diversity of mode of action, reu...

Drug Resistance in Bacteria, Fungi, Malaria, and Cancer
  • Language: en
  • Pages: 629

Drug Resistance in Bacteria, Fungi, Malaria, and Cancer

  • Type: Book
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  • Published: 2017-03-21
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  • Publisher: Springer

This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Soft Computing for Biological Systems
  • Language: en
  • Pages: 301

Soft Computing for Biological Systems

  • Type: Book
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  • Published: 2018-02-19
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  • Publisher: Springer

This book explains how the biological systems and their functions are driven by genetic information stored in the DNA, and their expression driven by different factors. The soft computing approach recognizes the different patterns in DNA sequence and try to assign the biological relevance with available information.The book also focuses on using the soft-computing approach to predict protein-protein interactions, gene expression and networks. The insights from these studies can be used in metagenomic data analysis and predicting artificial neural networks.