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Progress in Medicinal Chemistry
Progress in Medicinal Chemistry
The Histamine H3 Receptor
In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). B...
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expectedto provide the basis for entirely new future therapies.
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry continues to focus on providing timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. - Annual comprehensive reviews of the past year literature in many topics of interest to medicinal chemists - Includes a comprehensive set of indices to easily locate topics in Volumes 1-38 of this series - Provides critical review on hot topics in medicinal chemistry
Phosgenations
In this manual, the authors compare the range of applications for phosgene with that of the alternative compounds, dealing in detail with the possible uses of diphosgene, triphosgene, carbon dioxide, organic carbonates, oxalylchloride and many other alternative materials used in synthesis. However, they clearly point out those cases where phosgene continues to have the advantage. The result is a mine of information for synthetic chemists working in industry and academia faced with the question of where the toxic phosgene can be replaced by an unproblematic compound - including the safety phosgenation.
G Protein-Coupled Receptors as Drug Targets
With its particular emphasis on the constitutive activity of G-protein-coupled receptors (GPCRs)s, this book comprehensively discusses an important biological process that has not yet been covered in such depth in any other existing books on GPCRs. The international team of highly distinguished authors addresses in detail current models and concepts, to introduce medicinal chemists, physiologists, pharmacologists, and medical researchers into the advances in the understanding of GPCR activation and constitutive activity. In addition, the book provides an overview on methods of investigating constitutive GPCR activity. The text is well illustrated by selected experimental data and schemes._Th...
Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des Recherches Pharmaceutiques
Volume 45 of "Progress in Drug Research" contains eight reviews and the various indexes which facilitate its use and establish the connection with the previous volumes. The articles in this volume deal with neuro peptides as native immune modulators, with Calmodulin and with effects of cell stimuli and drugs on cellular activation, with recent advances in benzodiazepine receptor binding studies, with the medicinal chemistry and therapeutic potentials of ligands of the histamine H3 receptor, with Serotonin uptake inhibitors, with computer-aided drug design, with natri uretic hormones and with the recent developments in the chemotherapy of osteoporosis. In the 36 years that PDR has existed, th...
Advances in Drug Research
Advances in Drug Research, Volume 20 focuses on the general themes of drug research and description of specific drug classes. This book is divided into four chapters. Chapter 1 discusses the extrapolation of toxicological and pharmacological data from animals to humans. The second chapter deals with the tissue binding of drugs, considering the relative ponderal importance of tissue versus blood macromolecules. The therapeutic use of plants and consumption of medicinal plants are elaborated in Chapter 3. The last chapter covers the field of histaminergic agonists and antagonists, describing breakthroughs such as H2-receptor antagonists, non-sedating H1-receptor antagonists, and H3-receptors. This publication is valuable to drug researchers and students interested in advances in drugs.
Comprehensive Medicinal Chemistry II
The first edition of Comprehensive Medicinal Chemistry was published in 1990 and was very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organis...
