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Peroxisomes
Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.
History of Electron Microscopy in Switzerland
I. Instrumentation.- The Instrumental Contribution of Switzerland to the Development of Electron Microscopy; A Historical Review.- The Swiss STEM Project.- II. The Pioneers.- The Beginning of Electron Microscopy in Zürich.- Chemical Electron Microscopy in Berne.- Early Times of Electron Microscopy in Geneva (1944-1964).- The 'Bernese Connection' of Early Pioneers in Biological Electron Microscopy.- III. Materials Science.- Electron Microscopy at the Batteile Laboratories in Geneva.- IV. Biology and Medicine.- The Contribution of Switzerland to the Development of Embedding Methods in Cytology.-
Hypolipidemic Agents
The major cause of death in the Western world is some form of vascular disease; and principal among these forms is atherosclerotic heart disease (ASHD). Although much is known about the etiology and treatment of ASHD, there is, as yet, no specific means of prognosis of an impending coronary episode. There are, however, several indications of susceptibility to coronary disease, generally known as risk factors, the foremost of which is hyperlipidemia. Hyperlipidemia is more commonly designated as hypercholesteremia or triglyceridemia, depending upon which moiety is elevated, but since lipids are transported in the blood as members of a lipoprotein complex, the most descriptive general term wou...
Biological Reactive Intermediates III
This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with t...
The Functioning Cytoplasm
This book was not written for contemporary scientists with a major interest in cell biology. Rather, it was prepared for the serious and inquiring student who mayor may not have had an extensive background in the sciences but who is interested in exploring or reviewing in depth the current body of knowledge about cellular structure and function. We have tried to convey a sense of the expectant excitement that characterizes the modem-day cellular biologist and we regret any scientific jargon that may have crept into the text as a result of this effort. We have selected and assimilated experiments done by numerous scien tists and have used them to explain how cells work. In doing this, we have...
Chemical Carcinogenesis
About two centuries after the communication by Sir Percival Pott that the "chimney sweeper disease" was a cancer and its suggestion that active compounds of soot were the causative agents, and about one century after the description of urinary bladder cancer in dye workers, an enormous number of substances have been synthesized and have probably come into contact with man. Research in cancer prevention is of primary importance, and may receive continuous support from new discoveries on cancer etiology and pathogenesis. If one accepts the multistage model of chemical carcinogenesis, one has also to accept that many events occur between the contact of carcino genic compounds and their specific targets and the development of a clinically recognizable neoplasm. Thus, animal studies become essential to elucidate the different steps by which chemical carcinogens induce neoplasia. The analysis of these steps and the comparative evaluation of experimental models is essential to an understanding of pathogenesis.
