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Bradley Fighting Vehicle
8 pages of full color illustrations depicting 14 different vehicles. The Bradley Fighting Vehicle was developed in the 1970s to counter the new Infantry Fighting Vehicles of the Soviet Union and its Warsaw Pact allies. Designed to survive the imagined high-intensity, Nuclear, Biological and Chemical (NBC) battlefield of the Cold War, it became, alongside the M1 Abrams Main Battle Tank, the mainstay of US armoured forces during the 1980s. As the Cold War ended, however, it would go on to prove its worth on other battlefields. During the First Gulf War the Bradley would destroy more Iraqi AFVs than the Abrams, while during the 1990s it would prove itself an effective weapons system in the miss...
The Holy Reich
Analyzing the previously unexplored religious views of the Nazi elite, Richard Steigmann-Gall argues against the consensus that Nazism as a whole was either unrelated to Christianity or actively opposed to it. He demonstrates that many participants in the Nazi movement believed that the contours of their ideology were based on a Christian understanding of Germany's ills and their cure. A program usually regarded as secular in inspiration - the creation of a racialist 'people's community' embracing antisemitism, antiliberalism and anti-Marxism - was, for these Nazis, conceived in explicitly Christian terms. His examination centers on the concept of 'positive Christianity,' a religion espoused by many members of the party leadership. He also explores the struggle the 'positive Christians' waged with the party's paganists - those who rejected Christianity in toto as foreign and corrupting - and demonstrates that this was not just a conflict over religion, but over the very meaning of Nazi ideology itself.
Molecular Analysis of B Lymphocyte Development and Activation
The B lymphocyte lineage represents an important paradigm for exploring the molecular mechanisms underlying cell fate specification, differentiation and cellular activation. In the past five years, major advances have been achieved in our understanding of the transcriptional control of early B cell development and terminal plasma cell differentiation. In addition new insights became available for the processes of B cell activation, class switch recombination and somatic hypermutation. Many of the new findings and their implications for a molecular understanding of B cell biology in particular and cell differentiation in general are covered in this volume.
Lesser Known Large dsDNA Viruses
Several large dsDNA-containing viruses such as poxviruses (smallpox) and herpes viruses are well known among the scientific community, as well as the general populace, because they cause human diseases. The large dsDNA insect-infecting baculoviruses are also well known in the scientific community because they are used both as biological control agents and as protein expression systems. However, there are other large dsDNA-containing viruses, including the giant 1.2 Mb mimivirus, which are less well known despite the fact that all of them play important roles in every day life. Seven of these virus families are reviewed in this book.
Xenotransplantation
Xenotransplantation could have an impact on at least three aspects of medicine. The first is as a means of overcoming a severe shortage of human donor organs for the treatment of organ failure. The second aspect relates to the possibility that a xenogeneic organ would not be susceptible to infection by a "human" virus and thus the xenograft might resist injury caused by such viruses. The third and, as of yet, unexplored aspect relates to a means of delivering genes for therapeutic purposes thus overcoming some of the limitations of "conventional" gene therapy.
Role of Apoptosis in Infection
(will follow)
TT Viruses
Eleven years ago the circular DNA of a novel single-stranded virus has been cloned and partially characterized by Nishizawa and Okamoto and their colleagues. According to the initials of the patient from whom the isolate originated, the virus was named TT virus. This name has been subsequently changed by the International Committee on Taxonomy of Viruses (ICTV) into Torque teno virus, permitting the further use of the abbreviation TTV. Although initially suspected to play a role in non A –E hepatitis, subsequent studies failed to support this notion. Within a remarkably short period of time it became clear that TT viruses are widely spread globally, infect a large proportion of all human populations studied thus far and represent an extremely heterogeneous group of viruses, now labelled as Anelloviruses. TT virus-like infections have also been noted in various animal species. The classification of this virus group turns out to be difficult, their DNA contains between 2200 and 3800 nucleotides, related so-called TT-mini-viruses and a substantial proportion of intragenomic recombinants further complicate attempts to combine these viruses into a unifying phylogenetic concept.
Phosphoinositides in Subcellular Targeting and Enzyme Activation
Cells of the immune system are activated by a variety of stimuli that are derived from other cells, ingested material or from invading microorganisms. This issue of CTMI focuses on the mechanisms of phosphoinositide-mediated protein recruitment to intracellular membranes.
Immunology, Phenotype First: How Mutations Have Established New Principles and Pathways in Immunology
This monograph deals with the impact of classical genetics in immunology, prov- ing examples of how large immunological questions were solved, and new fields opened to analysis through the study of phenotypes, either spontaneous or induced. As broad as biology has become, there are those who do not fully understand what the genetic approach is, and how it differs fundamentally from most of the methods available to natural scientists. They may hold the opinion that genetics has run its course since Mendel read his paper on peas in 1865. “Why bother with classical genetics,” they may ask. “Won’t all genes be knocked out soon anyway?” Or they are intimidated by genetics, with its heav...
Measles
Measles virus, one of the most contagious of all human viruses, has been largely contained by the development and use of a vaccine that was introduced 50 years ago. These two volumes were timed to honor the introduction of the vaccine and to record the enormous advancements made in understanding the molecular and cell biology, pathogenesis, and control of this infectious disease. Where vaccine has been effectively delivered, endemic measles virus transmission has been eliminated. However, difficulties in vaccine delivery, lack of health care support and objection to vaccination in some communities continue to result in nearly 40 million cases and over 300,000 deaths per year from measles.
