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The World Health Organization defines health as “a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity”, and its constitution also asserts that health for all people is “dependent on the fullest co-operation of individuals and States”. The ongoing pandemic has highlighted the power of both healthy and unhealthy information, so while healthcare and public health services have depended upon timely and accurate data and continually updated knowledge, social media has shown how unhealthy misinformation can be spread and amplified, reinforcing existing prejudices, conspiracy theories and political biases. This book presents the proce...
Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regener...
This publication, often referred to as the "Blue Book," lists the names, addresses, emails, website URLs and phone numbers of all diplomatic representatives to the United Nations headquarters in New York City. This includes UN Member States maintaining permanent missions in the City; Non-member Observer States and entities; intergovernmental organizations; other entities; specialized agencies maintaining liaison offices at headquarters, as well as members of the principal organs of the United Nations and members of other standing organs of the UN. This publication is written in conjunction with the United Nations Protocol and Liaison Service at headquarters.
This book illustrates the current state-of-the-art in histamine research, with a focus on the appropriate methodologies to investigate the pharmacological properties and the therapeutic exploitation of HRs and their ligands. In addition, the range of techniques described provides an introduction to complementary cross-methodological disciplines beyond these fields. This multi-disciplinary approach is required to define the ‘decision gates’ that determine the development of more effective and safer therapeutic options for many forms of highly prevalent and debilitating diseases, such as asthma, dementias, dermatitis, and arthritis. Written for the Methods in Pharmacology and Toxicology series, chapters concentrate on practical, hands-on protocols from experts in the techniques. Authoritative and thorough, Histamine Receptors as Drug Targets seeks to aid pharmacologists, biochemists, drug discovery researchers, molecular biologists, chemists, toxicologists, lab scientists, medical doctors, principle investigators, research scientists, lab directors and technicians, as well as graduate students around the world in pursuing the study of this vital scientific area.
The introduction and rapid spread of two Eurasian mussel species, Dreissena polymorpha (zebra mussel) and Dreissena rostriformis bugensis (quagga mussel), in waters of North America has caused great concern among industrial and recreational water users. These invasive species can create substantial problems for raw water users such as water treatme
Performance measurement remains a vexing problem for business firms and other kinds of organisations. This book explains why: the performance we want to measure (long-term cash flows, long-term viability) and the performance we can measure (current cash flows, customer satisfaction, etc.) are not the same. The 'balanced scorecard', which has been widely adopted by US firms, does not solve these underlying problems of performance measurement and may exacerbate them because it provides no guidance on how to combine dissimilar measures into an overall appraisal of performance. A measurement technique called activity-based profitability analysis (ABPA) is suggested as a partial solution, especially to the problem of combining dissimilar measures. ABPA estimates the revenue consequences of each activity performed for the customer, allowing firms to compare revenues with costs for these activities and hence to discriminate between activities that are ultimately profitable and those that are not.
A co-publication of the World Bank, International Finance Corporation and Oxford University Press