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Endorphins and Opiate Antagonists in Psychiatric Research
The discovery of new molecules that function in neuronal communication can be viewed as a progression of steps beginning with the identification of the molecular structure, moving to the understanding of the mecha nisms mediating the synaptic action, and to the appraisal of the involve ment of the new molecules in various neuronal mechanisms, and finally reaching the evaluation of this molecule's role in brain function and the consequences that are triggered by its abnormalities. Enkephalins have followed such a pattern, and the present publication expresses the salient points of the last two phases in this succession. Enkephalins were discovered in December 1975; in addition to pain thresho...
Published Scientific Papers of the National Institutes of Health
Each issue lists papers published during the preceding year.
Psychopharmacology and Aging
This volume represents the proceedings of a Symposium on Psychopharmacology and the Aging Patient, held at Duke University, May 29-31, 1972. The conference was jointly sponsored by the Center for the Study of Aging and Human Development and the Department of Psychiatry at Duke. This Symposium was the first in a series of conferences which will be devoted variously to preclinical and clinical pharmacology of the different groups of psychotropic drugs, especially as they relate to the problems of the elderly patient and to the special considerations that must be given in theory and in practice to changes brought about by the process of aging. The idea behind this particular symposium was to br...
Lithium
Psychopharmacology has certainly had the greatest impact on psy chiatric theory and practice since the psychoanalytic discoveries by Freud. Beginning more than 20 years ago, psychopharmacology has become a vigorous interdisciplinary science, and over the last 10 to 15 years has witnessed a tremendous growth both from a scientific and practical point of view. Lithium occupies a unique and central position in modern psycho pharmacology for several reasons. The introduction of the lithium ion in 1949 as a psychoactive drug preceded the advent of reserpine or chlorprom azine and placed it as the first agent in the modern era of pharmacopsy chiatry. In fact, this first report on the use of lithiu...
Current Trends in Lithium and Rubidium Therapy
Lithium research and therapy needs to be continually re-evaluated on the basis of modern methodological approaches in order to shed new light on the mechanism of action and to improve therapeutic use. This book. based on the proceedings of the "International Meeting on Lithium and Rubidium Therapy" held in Venice from September 30th to October 2nd 1983. is devoted to current trends in the pharmacology and clinical aspects of lithium and of a newly born therapeutic cation. rubidium. The first part of this volume deals with modern trends in behavioural and biochemical approaches to the mechanism of action of lithium. A larger consideration is reserved for lithium therapy from a clinical point ...
Models of Depressive Disorders
This volume is the second in a series on depressive illness. The first volume, entitled Phenomenology of Depressive Illness, is de voted to a description of depressive illness from many vantage points including that of the patient as well as the psychiatrist. Epidemiological, nosological, and developmental aspects are included together with specific descriptions of major subtypes of depressive illness. It is only after an illness is fully described that an attempt should be made to generate models with ex planatory and predictive properties. This second volume is that next step. The major models of depressive illness are described. The limited progress that has been made in integrating these...
