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Design and Analysis of Experiments and Observational Studies using R
Introduction to Design and Analysis of Scientific Studies exposes undergraduate and graduate students to the foundations of classical experimental design and observational studies through a modern framework - The Rubin Causal Model. A causal inference framework is important in design, data collection and analysis since it provides a framework for investigators to readily evaluate study limitations and draw appropriate conclusions. R is used to implement designs and analyse the data collected. Features: Classical experimental design with an emphasis on computation using tidyverse packages in R. Applications of experimental design to clinical trials, A/B testing, and other modern examples. Discussion of the link between classical experimental design and causal inference. The role of randomization in experimental design and sampling in the big data era. Exercises with solutions. Instructor slides in RMarkdown, a new R package will be developed to be used with book, and a bookdown version of the book will be freely available. The proposed book will emphasize ethics, communication and decision making as part of design, data analysis, and statistical thinking.
Biometrics - Volume I
Biometrics is a component of Encyclopedia of Mathematical Sciences in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. Biometry is a broad discipline covering all applications of statistics and mathematics to biology. The Theme Biometrics is divided into areas of expertise essential for a proper application of statistical and mathematical methods to contemporary biological problems. These volumes cover four main topics: Data Collection and Analysis, Statistical Methodology, Computation, Biostatistical Methods and Research Design and Selected Topics. These volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
Randomization in Clinical Trials
Praise for the First Edition “All medical statisticians involved in clinical trials should read this book...” - Controlled Clinical Trials Featuring a unique combination of the applied aspects of randomization in clinical trials with a nonparametric approach to inference, Randomization in Clinical Trials: Theory and Practice, Second Edition is the go-to guide for biostatisticians and pharmaceutical industry statisticians. Randomization in Clinical Trials: Theory and Practice, Second Edition features: Discussions on current philosophies, controversies, and new developments in the increasingly important role of randomization techniques in clinical trials A new chapter on covariate-adaptive...
Cluster Randomization Trials
Oftentimes, small groups (called clusters) of individuals (called subunits) are randomized between treatment arms. Typically, clusters are families, classes, communities, surgeons operating patients, and so on. Such trials are called cluster randomization trials (CRTs). The subunits in each cluster share common frailties so that their outcomes tend to be positively correlated. Since clusters are independent, the data in two arms are independent in CRTs. In a clinical trial, multiple sites (such as teeth or ears) from each subject may be randomized between different treatment arms. In this case, the sites (subunits) of each subject (cluster) share common genetic, physiological, or environment...
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Statistics Today
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From Identity to Mondialisation
TheatreWorks is renowned for its daring, and sometimes controversial, productions. Since its inception the company has explored important social issues such as sexuality, censorship and oppression. The company also pioneered different types of productions; it introduced the black box theatre to Singapore and staged epic outdoor festivals in Fort Canning Park. This book, celebrating TheatreWorks 25th anniversary, charts the company’s evolution from a small theatre cooperative working from a terrace house to the well-respected innovator in the Singapore theatre community. From Identity to Mondialisation: TheatreWorks 25 is a stunning visual history of the company, featuring photography from many of TheatreWorks’ groundbreaking performances and quotes and anecdotes from members of the company, past and present.
Tutorials in Biostatistics, Statistical Methods in Clinical Studies
The Tutorials in Biostatistics have become a very popular feature of the prestigious Wiley journal, Statistics in Medicine (SIM). The introductory style and practical focus make them accessible to a wide audience including medical practitioners with limited statistical knowledge. This book represents the first of two volumes presenting the best tutorials published in SIM, focusing on statistical methods in clinical studies. Topics include the design and analysis of clinical trials, epidemiology, survival analysis, and data monitoring. Each tutorial is focused on a medical problem, has been fully peer-reviewed and edited, and is authored by leading researchers in biostatistics. Many articles include an appendix on the latest developments since publication in the journal and additional references. This will appeal to statisticians working in medical research, as well as statistically-minded clinicians, biologists, epidemiologists and geneticists. It will also appeal to graduate students of biostatistics.
MODA 5 - Advances in Model-Oriented Data Analysis and Experimental Design
This volume contains the majority of the papers presented at the 5th Inter national Workshop on Model-Oriented Data Analysis held in June 1998. This series started in March 1987 with a meeting on the Wartburg, Eisenach (Germany). The next three meetings were in 1990 (St Kyrik monastery, Bulgaria), 1992 (Petrodvorets, StPetersburg, Russia) and 1995 (Spetses, Greece). The main purpose of these workshops was to bring together lead ing scientists from 'Eastern' and 'Western' Europe for the exchange of ideas in theoretical and applied statistics, with special emphasis on experimen tal design. Now that the separation between East and West has become less rigid, this dialogue has, in principle, bec...
