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An important factor that affects the duration, complexity and cost of a clinical trial is the endpoint used to study the treatment’s efficacy. When a true endpoint is difficult to use because of such factors as long follow-up times or prohibitive cost, it is sometimes possible to use a surrogate endpoint that can be measured in a more convenient or cost-effective way. This book focuses on the use of surrogate endpoint evaluation methods in practice, using SAS and R.
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The second edition of A Life Course Approach to Women's Health is a timely addition to the literature, reflecting extraordinary gains in the evidence on women's health across the life course. This new edition provides an up to date and comprehensive review of scientific evidence and methodological developments in life course epidemiology, as well as new fields of research, such as integrative omics. This text reflects the focus of recent research, advances in technology, and the evolving nature of the field with its application in practice and policy. There are new chapters on endometriosis, lung function, cognition, gynaecological cancer, integrative omics, structural sexism, violence, heal...
In this book, the authors embark on a critical investigation of the complex field of Chinese language education, with a particular focus on exploring new trends and teaching and learning. They delve into the intricacies of language, education and its effectiveness in teaching Chinese as a first language. The book has three objectives: establishing a field of study in Chinese language learning and teaching, providing critical discussion and progressive insights on language education, and offering relevant pedagogical perspectives of learning and teaching Chinese as L1 and L2. The chapters investigate learning and teaching of Chinese in different aspects, including four skills, culture, litera...
Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in the design and analysis of safety studies are discussed with illustrative applications and examples. Medical Product Safety Evaluation: Biological Models and Statistical Methods presents cutting-edge biological models and statistical methods that are tailored to specific objectives and data types for safety analysis and benefit-risk assessment. Some frequently encountered issues and challenges in t...
This annual directory has been revised and updated for 1999 to provide a comprehensive source of information on the major public and private companies of Western Europe. It includes detailed information on each of the 24,000 companies featured over the four volume set.
Repeated Measures Design with Generalized Linear Mixed Models for Randomized Controlled Trials is the first book focused on the application of generalized linear mixed models and its related models in the statistical design and analysis of repeated measures from randomized controlled trials. The author introduces a new repeated measures design called S:T design combined with mixed models as a practical and useful framework of parallel group RCT design because of easy handling of missing data and sample size reduction. The book emphasizes practical, rather than theoretical, aspects of statistical analyses and the interpretation of results. It includes chapters in which the author describes some old-fashioned analysis designs that have been in the literature and compares the results with those obtained from the corresponding mixed models. The book will be of interest to biostatisticians, researchers, and graduate students in the medical and health sciences who are involved in clinical trials. Author Website:Data sets and programs used in the book are available at http://www.medstat.jp/downloadrepeatedcrc.html