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Recent Advances in Cell Biology of Acute Leukemia
The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints ...
Desperate Remedies
A Telegraph Book of the Year A Washington Post Notable Work A Times Book of the Year A Hughes Award Finalist “An indisputable masterpiece...comprehensive, fascinating, and persuasive.” —Wall Street Journal “Brimming with wisdom and brio, this masterful work spans the history of psychiatry. Exceedingly well-researched, wide-ranging, provocative in its conclusions, and magically compact, it is riveting from start to finish. Mark my words, Desperate Remedies will soon be a classic.” —Susannah Cahalan, author of Brain on Fire “Compulsively readable...Scull has joined his wide-ranging reporting and research with a humane perspective on matters that many of us continue to look away f...
Better Doctors, Better Patients, Better Decisions
How eliminating “risk illiteracy” among doctors and patients will lead to better health care decision making. Contrary to popular opinion, one of the main problems in providing uniformly excellent health care is not lack of money but lack of knowledge—on the part of both doctors and patients. The studies in this book show that many doctors and most patients do not understand the available medical evidence. Both patients and doctors are “risk illiterate”—frequently unable to tell the difference between actual risk and relative risk. Further, unwarranted disparity in treatment decisions is the rule rather than the exception in the United States and Europe. All of this contributes t...
Leukocyte Typing II
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Virus Mania
"The book 'Virus Mania' has been written with the care of a master-craftsman, courageously evaluating the medical establishment, the corporate elites and the powerful government funding institutions." Wolfgang Weuffen, MD, Professor of Microbiology and Infectious Epidemiology "The book 'Virus-Wahn' can be called the first work in which the errors, frauds and general misinformations being spread by official bodies about doubtful or non-virus infections are completely exposed." Gordon T. Stewart, MD, professor of public health and former WHO advisor - - - The population is terrified by reports of so-called COVID-19, measles, swine flu, SARS, BSE, AIDS or polio. However, the authors of "Virus M...
Stepping Back and Looking Ahead: Twelve Years of Studying Religious Contact at the Käte Hamburger Kolleg Bochum
This book includes a collection of articles by leading researchers on the topic of religious contact in the study of religion. Resulting from the final conference of the Käte Hamburger Kolleg "Dynamics in the History of Religions"–one of the largest research initiatives in the interdisciplinary study of religion worldwide in recent years (2008-2020)—this book encapsulates the twofold aim of this conference: first, to "step back" and reflect upon the merits and challenges of studying religious dynamics as a result of intra-, inter-, and extra-religious contact, and second "to look beyond" and pave ways for future approaches to study religion as a social phenomenon.
Integrative Problem-Solving in a Time of Decadence
Presents a unique study of Integrative Problem-Solving (IPS). The consideration of 'Decadence' is essential in the scientific study of environmental and other problems and their rigorous solution, because the broad context within which the problems emerge can affect their solution. Stochastic reasoning underlines the conceptual and methodological framework of IPS, and its formulation has a mathematical life of its own that accounts for the multidisciplinarity of real world problems, the multisourced uncertainties characterizing their solution, and the different thinking modes of the people involved. Only by interpolating between the full range of disciplines (including stochastic mathematics, physical science, neuropsychology, philosophy, and sociology) and the associated thinking modes can scientists arrive at a satisfactory account of problem-solving, and be able to distinguish between a technically complete problem-solution, and a solution that has social impact.
Leukemia and Lymphoma
In Leukemia and Lymphoma: Detection of Minimal Residual Disease, hands-on experts describe and discuss the minimal residual disease (MRD) methods they have successfully pioneered for leukemias and lymphomas. They apply reverse transcription PCR (RT-PCR) to acute myeloid leukemia (AML), chronic myelogenous leukemia (CML), and acute promyelocytic leukemia (APL). Other PCR methods are used for Non-Hodgkin's Lymphoma and for the monitoring of follicular lymphoma. Additional chapters address the use of real-time quantitative PCR (RQ-PCR), the emergent method of choice, in patients with acute lymphoblastic leukemia (ALL), the evaluation of MRD techniques in clinical trials, and the application of flow cytometry techniques.
Individualized Medicine
In 2009 the University Medicine Greifswald launched the “Greifswald Approach to Individualized Medicine” (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes – next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients – chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.
Improving Medical Outcomes
The problems faced by medical doctors and automobile mechanics are in some ways quite similar—something isn't working right and must be fixed. They must both figure out the cause of malfunctions and determine the appropriate treatments. Yet, the mechanic has no need to worry about an automobile's psyche; the specific mechanical factors are the only ones that come into play. In health care, however, the factors influencing outcomes are broader, more complicated, and colored by the underlying psychological factors of those involved. These factors have profound effects. Doctors are often influenced by patients' description of symptoms, yet information is often incomplete or inaccurate or colo...
