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The Golden Threads
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Chirality in Drug Research
Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.
Data Stream Management
This volume focuses on the theory and practice of data stream management, and the novel challenges this emerging domain poses for data-management algorithms, systems, and applications. The collection of chapters, contributed by authorities in the field, offers a comprehensive introduction to both the algorithmic/theoretical foundations of data streams, as well as the streaming systems and applications built in different domains. A short introductory chapter provides a brief summary of some basic data streaming concepts and models, and discusses the key elements of a generic stream query processing architecture. Subsequently, Part I focuses on basic streaming algorithms for some key analytics...
Weimar Radicals
Exploring the gray zone of infiltration and subversion in which the Nazi and Communist parties sought to influence and undermine each other, this book offers a fresh perspective on the relationship between two defining ideologies of the twentieth century. The struggle between Fascism and Communism is situated within a broader conversation among right- and left-wing publicists, across the Youth Movement and in the "National Bolshevik" scene, thus revealing the existence of a discourse on revolutionary legitimacy fought according to a set of common assumptions about the qualities of the ideal revolutionary. Highlighting the importance of a masculine-militarist politics of youth revolt operative in both Marxist and anti-Marxist guises, Weimar Radicals forces us to re-think the fateful relationship between the two great ideological competitors of the Weimar Republic, while offering a challenging new interpretation of the distinctive radicalism of the interwar era.
Algorithmic Learning Theory
This book constitutes the refereed proceedings of the 16th International Conference on Algorithmic Learning Theory, ALT 2005, held in Singapore in October 2005. The 30 revised full papers presented together with 5 invited papers and an introduction by the editors were carefully reviewed and selected from 98 submissions. The papers are organized in topical sections on kernel-based learning, bayesian and statistical models, PAilearning, query-learning, inductive inference, language learning, learning and logic, learning from expert advice, online learning, defensive forecasting, and teaching.
