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Principles of Cancer Treatment and Anticancer Drug Development
This book explains how current medicines against cancer work and how we find new ones. It provides an easy-to-understand overview of current options to treat patients with cancer, which includes Surgery, Radiation therapy, Chemotherapy, Targeted therapy and Immunotherapy. The efficiency of all these treatments is limited by the capacity of cancer cells to escape therapy. This book explains the mechanisms of anti-cancer drug resistance and strategies to overcome it. The discovery and development process of a new drug is detailed beginning with the identification and validation of a therapeutic target, the identification of an inhibitor of the target and its subsequent preclinical and clinical...
Taxing Profit in a Global Economy
The international tax system is in dire need of reform. It allows multinational companies to shift profits to low tax jurisdictions and thus reduce their global effective tax rates. A major international project, launched in 2013, aimed to fix the system, but failed to seriously analyse the fundamental aims and rationales for the taxation of multinationals' profit, and in particular where profit should be taxed. As this project nears its completion, it is becomingincreasingly clear that the fundamental structural weaknesses in the system will remain. This book, produced by a group of economists and lawyers, adopts a different approach and starts from first principles in order to generate an ...
International Manual of Oncology Practice
This textbook addresses themes ranging from the molecular issues of cancer sciences to clinical practice in medical oncology. It clarifies many topics, including molecular oncology, chemotherapy pharmacology and practical issues for clinicians. Systemic treatments in many areas of oncology feature, such as breast cancer, gastrointestinal, thoracic, urological oncology, head and neck tumors, bone tumors, sarcomas and palliative care. An excellent source for young physicians and researchers in the field of oncology, this book furthers understanding of medical oncology practice and facilitates professionals’ treatment of cancer patients. It sets the direction for future research in the field, and will become the readers’ regular working tool.
Chemical agriculture and pollinators: signs of a Planet in danger
Bees, that have inhabited the Planet for over 100 million years, are the common thread that tells the story of various ecological challenges such as the reduction of biodiversity, climate change, soil degradation, and energy transition. Paradoxically, agriculture is one of the major causes of irreversible and, therefore, unsustainable changes such as global warming and the extinction of pollinators from which it derives its benefits and wealth. The massive use of fossil fuels, the distribution of poisons such as pesticides (persistent, toxic, and bioaccumulative), the loss of fertility in monocultures of plants selected to satisfy economic needs, are some of the main causes of an ecologically unsustainable food production system. The book tries to show a different vision of the World we are building, a story of backstories and underestimated dangers. This book received two prizes: "Steli di Pace" (Stems of Peace) by the Union of European Journalists and Communicators in 2023 and it was the winner of the "Concorso Nazionale per la divulgazione scientifica Kerit-LC Edizioni" (National Competition for science dissemination) in 2024.
FOXO Transcription Factors
This volume provides an overview of experimental procedures and state-of art methods to investigate FOXOs. Chapters guide readers through biochemical and molecular methods, imaging approaches to monitor the subcellular localization of FOXO factors, omics and bioinformatics approaches, different animal models used in FOXO research, and human studies to investigate the role of FOXO factors in human disease and longevity. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge FOXO Transcription Factors: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Video and Multimedia Transmissions over Cellular Networks
This excellent reference provides detailed analysis and optimization aspects of live 3G mobile communication networks Video and Multimedia Transmissions over Cellular Networks describes the state-of-the-art in the transmission of multimedia over cellular networks, evaluates the performance of the running system based on the measurements and monitoring of live networks, and finally presents concepts and methods for improving of the quality in such systems. Key Features: Addresses the transmission of different media over cellular networks, with a focus on evolving UMTS transmission systems Provides in-depth coverage of UMTS network architecture, and an overview of 3GPP video services Describes...
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