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Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
This book constitutes the refereed proceedings of the 7th International Conference on Wireless Algorithms, Systems, and Applications, WASA 2012, held in Yellow Mountains, China, in August 2012. The 24 revised full papers presented together with 32 invited papers were carefully reviewed and selected from 116 submissions. The papers cover a wide range of topics such as cognitive radio networks, cyber-physical network systems, mobile handset networking systems, underwater and radar wireless networks, and wireless and mobile security.
This book constitutes the refereed proceedings of the 5th International Conference on Audio- and Video-Based Biometric Person Authentication, AVBPA 2005, held in Hilton Rye Town, NY, USA, in July 2005. The 66 revised oral papers and 50 revised poster papers presented were carefully reviewed and selected from numerous submissions. The papers discuss all aspects of biometrics including iris, fingerprint, face, palm print, gait, gesture, speaker, and signature; theoretical and algorithmic issues are dealt with as well as systems issues. The industrial side of biometrics is evident from presentations on smart cards, wireless devices, and architectural and implementation aspects.
This volume presents 14 experimental studies of lexical tone and intonation in a wide variety of languages. Six papers deal with the discriminability or the function of intonation contours and lexical tones in specific languages, as established on the basis of listener responses, as well as with brain activation patterns resulting from the perception of tonal and intonational stimuli. The remaining eight papers report on detailed phonetic findings on a variety of tonal phenomena in a number of languages, including declination in tone languages, final lowering, consonant-tone interactions and pitch target alignment.
In recent years, prosodic competence has become increasingly important in second language acquisition studies, as it is a crucial element in the identification of non-native pronunciation and message understanding. This volume is the first attempt to provide a survey of interlanguage prosody research in L2 Italian. It begins with an overview of the possible approaches to the study of rhythmic-prosodic skills acquisition in an L2. The second part of the book emphasizes the relationship between the mother tongue and a second language, and investigates the presence of transfer in prosody interlanguage development. The third part illustrates prosody’s role in the interpretation of pragmatic meaning in native-non-native interaction, and its influence on message persuasiveness. And in the fourth part, technology meets prosody in the areas of second language teaching and speech synthesis.
This book constitutes the refereed proceedings of the 16th Asia-Pacific Conference APWeb 2014 held in Changsha, China, in September 2014. The 34 full papers and 23 short papers presented were carefully reviewed and selected from 134 submissions. The papers address research, development and advanced applications of large-scale data management, web and search technologies, and information processing.