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Auditory System
nerve; subsequently, however, they concluded that the recordings had been from aberrant cells of the cochlear nucleus lying central to the glial margin of the VIII nerve (GALAMBOS and DAVIS, 1948). The first successful recordmgs from fibres of the cochlear nerve were made by TASAKI (1954) in the guinea pig. These classical but necessarily limited results were greatly extended by ROSE, GALAMBOS, and HUGHES (1959) in the cat cochlear nucleus and by KATSUKI and co-workers (KATSUKI et at. , 1958, 1961, 1962) in the cat and monkey cochlear nerve. Perhaps the most significant developments have been the introduction of techniques for precise control of the acoustic stimulus and the quantitative ana...
CCN proteins in health and disease
The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th interna...
Beyond Diversity
None
Edhf 2002
Understanding the nature and role of endothelium-derived hyperpolarizing factor is crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion, and other vascular disorders. EDHF 2002 is based on the proceedings of the Fourth International Symposium on endothelium-dependent hyperpolarizations. It will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.
The Endothelium
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases,...
The Endothelium, Part II
The endothelium controls vascular tone by releasing various vasoactive substances. Additionally, another pathway associated with the hyperpolarization of both endothelial and vascular smooth muscle cells contributes also to endothelium-dependent relaxations (EDHF-mediated responses). These responses involve an increase in the intracellular Ca concentration of the endothelial cells followed by the opening of Ca-activated K channels of small and intermediate conductances (SKCa and IKCa). These channels show a distinct subcellular distribution, suggesting that their activation could be elicited by distinct stimuli. Following KCa activation, the endothelial hyperpolarization can be conducted to ...
Transgenic Crops V
The status of crop biotechnology before 2001 was reviewed in Transgenic Crops I-III, but recent advances in plant cell and molecular biology have prompted the need for new volumes. This volume is devoted to fruit, trees and beverage crops. It presents the current knowledge of plant biotechnology as an important tool for crop improvement and includes up-to-date methodologies.
Index Medicus
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
