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The Laboratory Mouse
Among animals used in research, teaching and testing, mice are now widely recognized as the most important model for human diseases and disorders. They comprise the majority of all experimental mammals and tend to be the model of choice used for research into many diseases/disorders including cancer, heart disease, asthma, Alzheimer’s, Down syndrome, deafness, osteoporosis, obesity, diabetes and even mental health research. Additionally the laboratory mouse continues to play a widely publicized vital role in the human genome project.One of the most time-consuming activities in research laboratories is looking up information specific to the species or strain of animal being used. This book, part of the highly successful Handbook of Experimental Animals series, allows the user quick access to any point of interest on the mouse as an experimental model. * Edited by Hans Hedrich, Hannover Medical School* Comprehensive reference source written by international experts* Well-illustrated with high quality detailed images* Two-color, user-friendly format combined with color plate sections
Practical Handbook of Neurosurgery
“Practical Handbook of Neurosurgery” invites readers to take part in a journey through the vast field of neurosurgery, in the company of internationally renowned experts. At a time when the discipline is experiencing a (detrimental) tendency to segment into various subfields and scatter in the process, it can be worthwhile to collect a number of practical lessons gleaned from experienced and leading neurosurgeons. The book also aims to present numerous important figures in the neurosurgical community, with a brief overview of the vitae and main contributions for each. We must confess that we were sad that some of the most active members were unable to participate, likely due to time cons...
Controlled Nanoscale Motion
When the size of a machine approaches the nanometer scale, thermal fluctuations become large compared to the energies that drive the motor. The control of motion at the nanoscale therefore requires physical understanding and technical approaches that are fundamentally different from those that are successful at the macroscale. This volume provides an introduction to the state-of-the-art of controlled nanoscale motion in biological and artificial systems. Topics include the control and function of protein motors, the physics of non-equilibrium Brownian motion, and the physics and fabrication of synthetic molecular motors. The chapters in this book are based on selected contributions on the 2005 Nobel Symposium to Controlled Nanoscale Motion and are written by leading experts in their fields.
Neurosurgical Management of Aneurysmal Subarachnoid Haemorrhage
The small neck of the aneurysm afforded an easy surgical attack. An ordinary flat silver clip was placed over the sac and tightly compressed obliterated it completely. The clip was flush with the wall of the carotid artery. The sac, lateral to the silver clip, was then picked up with the forceps and thrombosed by the electocautery. Walter Dandy reporting his successful operation of a posterior communicating aneurysm on March 23, 1937. Walter Dandy's patient left the hospital in good health 2 weeks later, and from his report one may gain the impression that the operation was an easy task. Despite continuous developments during the following decades, it was not until the introduction of the op...
Mechanisms in Carcinogenesis and Cancer Prevention
A large proportion of cancers is preventable. External factors, discovered by epidemiological studies during the last 50 years, account for a majority of all cancer deaths. However, still rather little is known, about how environmental and genetic factors interact, how they may regulate gene activation etc. And it is a long way from the discovery of a basic regulatory mechanism to practical patient treatment. This volume describes the present state of the art in carcinogenesis, possibilities for cancer prevention, and gives genetic background in cancer development. Attention is given to the host-environment interaction, considering how this interaction may lead to cancer formation and how it can be utilised in cancer prevention. The molecular basis for cancer development and the molecular basis for prevention are described.
The Molecular Immunology of Complex Carbohydrates-3
Based on the third symposium on “Molecular Immunology of Complex Carbohydrates,” this text covers the latest in glycotopes, structures and functions of complex carbohydrates, recognition factors of lectins, biomolecular interactions and other glycosciences. This volume highlights the informative events of the Symposium on Molecular Immunology of Complex Carbohydrates III, held at the Institute of Biological Chemistry, Academia Sinica, on July 15-20, 2007, in Taipei, Taiwan.
Progress in Stem Cell Applications
This book is devoted to recent research in stem cell applications. Stem cells are the foundation cells for every organ, tissue and cell in the body. They are like a blank microchip that can ultimately be programmed to perform any number of specialised tasks. Stem cells are undifferentiated, "blank" cells that do not yet have a specific function. Under proper conditions, stem cells begin to develop into specialised tissues and organs. Additionally, stem cells are self-sustaining and can replicate themselves for long periods of time. These unique characteristics make stem cells very promising for supplying cells to treat debilitating diseases like Alzheimer's disease, cancer, Parkinson's disease, type-1 diabetes, spinal cord injury, stroke, burns, heart disease, osteoarthritis and rheumatoid arthritis.
Brain Tumors
Exciting new developments and discoveries of the last two decades are beginning to shed light on the complex biology of brain tumors and are advancing our understa- ing of the cellular and molecular processes involved in their initiation, progression, and clinical and biological behavior. The disease process in brain tumors is quite complex and the resulting tumors are characterized by a high degree of biological and clinical diversity. Thus, despite the advances of the last two decades, prognosis for patients with malignant brain tumors remains abysmal. Significant progress in the diagnosis, treatment and, ultimately, prevention of these tumors will require both the timely h- nessing of the...
Moyamoya Disease Update
Moyamoya disease (MMD) was first reported as a new entity among vascular disorders in 1957. Named for the abnormal vascular networks found around the occluded distal internal carotid artery, it is the most common pediatric cerebrovascular disease in East Asia. In recent years large amounts of data on MMD have been collected and important investigations have been carried out in Japan and Korea, even as the pathophysiology of the disease remains to be discovered. This monograph covers a diversity of topics and presents a systematic compilation of the data and current status of MMD in clinical practice and basic research. With contributions by more than 70 authors, the book includes sections on genetics, computational analysis of hemodynamic shear stress, new imaging techniques, and endovascular treatment of MMD, along with practical applications and future directions for gene and stem cell therapies. For neurosurgeons as well as neurologists and pediatricians, this volume will help lead to more efficient and informed management of MMD.
Polymers as Biomaterials
Nearly 4000 years ago, the Egyptians used linen, a natural polymeric material, for suturing wounds. About 600 B.C., the Indians used other forms of natural polymers such as cotton, horse hair, and leather in repairing wounds. Wound closure procedures using silk sutures, based mostly on polypeptides, are likely to have been practiced during the second century. Surgical application of natural polymers continued to represent the major use of polymers until the twentieth century. Not too long after the development of several major synthetic polymers, their use in biomedical applications has attracted the attention of many re searchers and clinicians. Over the past few years, interest in the biom...
