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Unmasking metabolic dependencies for anti-cancer treatment in cancer
Over the last decade, our understanding of metabolism in the context of cancer has evolved greatly. It is now evident that altered cellular metabolism is an integral effector of tumorigenesis that is intricately intertwined with cell signaling as well as genetic and epigenetic regulation of diverse tumor programs. Recognizing the dysregulation of cellular metabolism as an important aspect of tumor function has offered new potential direction to seek clinical benefit by providing targets for the development of novel therapeutics. To-date, several small molecule inhibitors that target tumor or immune cell metabolism are being explored in active clinical trials as either preventive, stand-alone, or adjuvant therapies for various malignancies. Thus, identifying critical metabolic vulnerabilities in pre-neoplastic cells, cancer cells, and immune cells has direct and timely relevance for developing additional treatment and preventative strategies against cancer.
Adoption of Artificial Intelligence in Human and Clinical Genomics, volume II
Large databases are created by genomics for the discovery, study, and development of novel treatments all around the world. It's not hard to conceive that artificial intelligence (AI) might currently study the 3 billion base pairs that make up humanoid genetic makeup in order to uncover genetic disparities among the population. By 2026, large pharmaceutical companies hope to have researched up to 2 million genomes and analyzed massive amounts of patient data from clinical drug studies. As new equipment is introduced, AI will be employed in genomics for a variety of omics investigations, including transcriptomics. To aid in the classification of potentially clinically significant genes, AI is...
Labor’s Share of Income
This book analyzes the decrease in labor share in China, which is a ratio of national income distribution to capital at three different levels (macro, meso, and micro) and from three different perspectives (growth, transition and opening up). The worsening income distribution has been a key issue for both Chinese and global economies in recent decades. The book shows that the decrease in labor share is closely related to economic growth, increasing extent of globalization, and firms with heterogeneous characteristics. Moreover, the book explains income inequality in detail, focusing on China’s increasingly important and emerging economy.
Daily Report
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Daily Report
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The Strongest Soldier King
Ye Feng, who once stood at the peak of the world and made the world tremble. Conspiracy had allowed him to be reborn into a useless cripple with the same surname and surname. And to see, how could Ye Feng return to the peak from being a loser. As long as I, Ye Feng, am not dead, I will make the world cry.
Super Male Instructor
Ten years later he was reincarnated but was surprised to find someone posing as himself as the head of the chinese power group which is hidden in what kind of conspiracy in order to solve the mystery. To save their own he sent for a body art training institutions male drillmaster led a team composed of beauty opened the modern city against the sky journey
