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Chemical Induction of Cancer
In the approach to the analysis of disease, including, of course, cancer, two major thrusts may be distinguished. These may be referred to, in shorthand, as agents and processes: the causative agents (chemical, microbial, physical, environmental, and psychosocial) and the organismic processes, initiated and furthered by the agents, culminating in observable pathology (at the macromolecular, cytological, histological, organ function, locomotor, and behavioral levels). The past 25 years, since the appearance of the first volume of the predecessor series (1) authored by the Editors of this present volume, have seen an impressive number of studies on chemicals (and other agents) as etiologic fac...
Aliphatic Carcinogens
Chemical Induction of Cancer: Structural Bases and Biological Mechanisms Volume IIIA deals with the organic and biochemical principles behind cancer. This volume contains the continuation of Volume IIA, which tackles structure-activity relationships of chemical carcinogens, the effect of chemical reactivity, molecular geometry, and metabolism on carcinogenic activity. Under this is non-conjugated organic compounds. The text is recommended for doctors, organic chemists, and biochemists with an advanced knowledge in biochemistry and organic chemistry and would like to know more the biochemical processes of cancer.
Recent Advances in QSAR Studies
This book presents an interdisciplinary overview on the most recent advances in QSAR studies. The first part consists of a comprehensive review of QSAR methodology. The second part highlights the interdisciplinary aspects and new areas of QSAR modelling.
Natural, Metal, Fiber, and Macromolecular Carcinogens
Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIC: Natural, Metal, Fiber, and Macromolecular Carcinogens covers structure-carcinogenicity relationships of carcinogenic mycotoxins, carcinogenic substances generated by plants, carcinogenic metals and metalloids, and foreign-body carcinogens. The book discusses the metabolism and mechanism of carcinogenic action, physicochemical properties, other biological activities (principally mutagenicity and teratogenicity), modification of carcinogenic activity, formation and environmental significance. The text also describes the carcinogenic water-soluble high polymers and explores the intriguing problems of the carc...
Aliphatic and Polyhalogenated Carcinogens
Chemical Induction of Cancer: Structural Bases and Biological Mechanisms, Volume IIIB: Aliphatic and Polyhalogenated Carcinogens covers environmentally and occupationally significant carcinogens of industrial origins. The book discusses the structure-activity relationships, metabolism, and environmental significance of the halogenated linear alkanes and alkenes and the halogenated cycloalkanes; and cycloalkene pesticides, biphenyls, and related aromatics. The text also describes the structure-activity relationships, metabolism, and environmental significance of the halogenated phenoxy acids, aromatic ethers, dibenzofurans, and dibenzo-p-dioxins; and ethylene glycol, diethylene glycol, dioxan...
Identifying Future Drinking Water Contaminants
With an increasing population, use of new and diverse chemicals that can enter the water supply, and emergence of new microbial pathogens, the U.S. federal government is faced with a regulatory dilemma: Where should it focus its attention and limited resources to ensure safe drinking water supplies for the future? Identifying Future Drinking Water Contaminants is based on a 1998 workshop on emerging drinking water contaminants. It includes a dozen papers that were presented on new and emerging microbiological and chemical drinking water contaminants, associated analytical and water treatment methods for their detection and removal, and existing and proposed environmental databases to assist in their proactive identification and regulation. The papers are preceded by a conceptual approach and related recommendations to EPA for the periodic creation of future Drinking Water Contaminant Candidate Lists (CCLsâ€"produced every five yearsâ€"include currently unregulated chemical and microbiological substances that are known or anticipated to occur in public water systems and that may pose health risks).
