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Multidisciplinary Approaches to The FLASH Radiotherapy
Radiotherapy (RT) is a cornerstone of cancer treatment, being routinely used for approximately half of cancer patients in high-income countries. Despite the extensive use of RT for over 60 years, its toxicity on normal tissues often limits the treatment of radioresistant tumors and is responsible for significant decrease in patient’s quality of life. However, it was recently established that ultra-high dose rate (UHDR) irradiation induces significantly less normal tissues toxicities, while keeping similar antitumor effect compared to conventional dose rate irradiation. This so called “FLASH Effect" was demonstrated in vivo on different animal models and different organs by delivering the total amount of radiation dose in a very short time ( usually <200 ms), with average dose rates above 40 Gy/s and with different particles including electrons, protons and photons.
Radiation Damage in Biomolecular Systems
Since the discovery of X-rays and radioactivity, ionizing radiations have been widely applied in medicine both for diagnostic and therapeutic purposes. The risks associated with radiation exposure and handling led to the parallel development of the field of radiation protection. Pioneering experiments done by Sanche and co-workers in 2000 showed that low-energy secondary electrons, which are abundantly generated along radiation tracks, are primarily responsible for radiation damage through successive interactions with the molecular constituents of the medium. Apart from ionizing processes, which are usually related to radiation damage, below the ionization level low-energy electrons can indu...
Ionizing Radiation and the Immune Response - Part A
Ionizing Radiation and the Immune Response, Volume 376, Part A reviews the latest updates on the immune response induced by ionizing radiations. Sections discuss NK functions in radio-induced immune response, TRT and immune response, Radio-induced immune response and lipid metabolism, Effect of protons and heavy ions on immune response, Effect of flashtherapy and mini beam on immune response, Radio-induced lymphopenia, CT to potentiate radio-induced immune response, Impact of RT on healthy tissues (inflammation), Radio-induced macrophagic response, To use nanoparticles and ionizing radiations to modulate immune response: opinion of the chemist, biologist and clinician, and more. Additional s...
World Congress on Medical Physics and Biomedical Engineering September 7 - 12, 2009 Munich, Germany
Present Your Research to the World! The World Congress 2009 on Medical Physics and Biomedical Engineering – the triennial scientific meeting of the IUPESM - is the world’s leading forum for presenting the results of current scientific work in health-related physics and technologies to an international audience. With more than 2,800 presentations it will be the biggest conference in the fields of Medical Physics and Biomedical Engineering in 2009! Medical physics, biomedical engineering and bioengineering have been driving forces of innovation and progress in medicine and healthcare over the past two decades. As new key technologies arise with significant potential to open new options in ...
The Carbon Age
What do bubbles in a soft drink, a bullet-proof vest, a plastic chair, and our DNA have in common? Carbon. It is, and forever has been, the ubiquitous architect of life and civilization, forming the chemical backbone of every living creature. And yet, when we hear the word today, it is more often than not in a crisis situation: carbon dioxide emissions are destroying the ozone layer and warming the planet; the volatile Middle East explodes atop its stores of hydrocarbons; carbohydrates threaten obesity and diabetics. Carbon, thus, sustains us and threatens us in equal measure, Eric Roston illuminates this essential element in all its forms, cleverly recreating the intricate carbon cycle on t...
Manual prático de escrita em português
Manual prático de escrita em português/Developing Writing Skills in Portuguese provides intermediate- and advanced-level students with the necessary skills to become competent and confident writers in the Portuguese language. With a focus on writing as a craft, Manual prático de escrita em português offers a rich selection of original materials including narrative texts, expository essays, opinion pieces and newspaper articles. Each chapter covers a specific kind of writing and is designed to help tackle the material in small units. The book aids students in crafting clear, coherent and cohesive texts by means of guided practice and step-by-step activities. Suitable for use as a classroom text or as a self-study course, this book is ideal for students at level B2 – C2 of the Common European Framework for Languages or at Intermediate High – Advanced High on the ACTFL proficiency scales.
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