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Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies
This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.
Business Intelligence and Information Technology
This book constitutes the refereed proceedings of the 2021 International Conference on Business Intelligence and Information Technology (BIIT 2021) held in Harbin, China, during December 18–20, 2021. BIIT 2021 is organized by the School of Computer and Information Engineering, Harbin University of Commerce, and supported by Scientific Research Group in Egypt (SRGE), Egypt. The papers cover current research in electronic commerce technology and application, business intelligence and decision making, digital economy, accounting informatization, intelligent information processing, image processing and multimedia technology, signal detection and processing, communication engineering and technology, information security, automatic control technique, data mining, software development, and design, blockchain technology, big data technology, artificial intelligence technology.
Prophets Unarmed
Prophets Unarmed is an authoritative sourcebook on the Chinese Communist Party's main early opposition, the Chinese Trotskyists, who emerged from the Chinese Communist Party, in China and Moscow, in reaction to its 1927 defeat. In spite of being Trotskyism’s main section outside Russia, they were crushed by Stalin in Moscow and by Chiang Kai-shek and Mao Zedong in China, thus becoming China’s most persecuted party. Their strategy in the Japan war, when they failed to take up arms, was short-sighted and doctrinaire, and they had scant impact on the revolution. Even so, their association with Chen Duxiu and Wang Shiwei, their attachment to democracy, and their critique of Mao’s bureaucratic socialism brought them a scintilla of recognition after Mao’s death. Their standpoints and proposals and their association with the democratic movement are not without relevance to China's present crisis of morals and authority.
Quality, Reliability, Security and Robustness in Heterogeneous Networks
This book constitutes the refereed conference proceedings of the 12th EAI International Conference on Quality, Reliability, Security and Robustness in Heterogeneous Networks, QShine 2016, held in Seoul, South Korea, in July 2016. The 27 full papers, 5 short papers and 18 workshop papers were selected from 85 submissions. The papers are organized thematically in tracks, starting with network security, followed by QoS, reliability and modeling, wireless and mobile networks. In addition the papers of two workshops are included: International Workshop on 5G Communication Architecture and Technology (5G-CAT 2016), and the 2nd International Workshop on Sensor Networks and Cloud Computing (SNCC 2016).
White Noise Analysis And Quantum Information
This volume is to pique the interest of many researchers in the fields of infinite dimensional analysis and quantum probability. These fields have undergone increasingly significant developments and have found many new applications, in particular, to classical probability and to different branches of physics. These fields are rather wide and are of a strongly interdisciplinary nature. For such a purpose, we strove to bridge among these interdisciplinary fields in our Workshop on IDAQP and their Applications that was held at the Institute for Mathematical Sciences, National University of Singapore from 3-7 March 2014. Readers will find that this volume contains all the exciting contributions by well-known researchers in search of new directions in these fields.
Positive Systems
This book presents high-quality original contributions on positive systems, including those with positivity in compartmental switched systems, Markovian jump systems, Boolean networks, interval observer design, fault detection, and delay systems. It comprises a selection of the best papers from POSTA 2018, the 6th International Conference on Positive Systems, which was held in Hangzhou, China, in August 2018. The POSTA conference series represents a targeted response to the growing need for research that reports on and critically discusses a wide range of topics concerning the theory and applications of positive systems. The book offers valuable insights for researchers in applied mathematics, control theory and their applications.
Multiphase Flow: The Ultimate Measurement Challenge
This volume contains peer-reviewed papers presented at the 5th International Symposium on Measurement Techniques for Multiphase Flows and 2nd International Workshop on Process Tomography. This symposium covers a wide scope of multiphase measurements including measurements. Advanced methods and recent researching developments in these fields are submitted for academic communication and discussion.
Advances in Computational Intelligence and Its Applications
It is with great pleasure and enthusiasm that we welcome you to the International Conference on Advances in Computational Intelligence and its Applications (ICACIA-2023). In the ever-evolving landscape of technology, computational intelligence stands as a cornerstone, shaping the future of diverse fields and industries. This conference serves as a nexus for researchers, academicians, and industry experts to converge, exchange ideas, and explore the latest advancements in the realm of computational intelligence.
Semiparametric Odds Ratio Model and Its Applications
Beginning with familiar models and moving onto advanced semiparametric modelling tools Semiparametric Odds Ratio Model and its Applications introduces readers to a new range of flexible statistical models and provides guidance on their application using real data examples. This books range of real-world examples and exploration of common statistical problems makes it an invaluable reference for research professionals and graduate students of biostatistics, statistics, and other quantitative fields. Key Features: Introduces flexible statistical models that have yet to systematically introduced in course materials. Discusses applications of the proposed modelling framework in several important statistical problems, ranging from biased sampling designs and missing data, graphical models, survival analysis, Gibbs sampler and model compatibility, and density estimation. Includes real data examples to demonstrate the use of the proposed models, and estimation and inference tools.
Ink Dances in Limbo
In this pioneering study of the entire written works of Gao Xingjian (高行健), China's first winner of the Nobel Prize for Literature, Jessica Yeung analyses each group of his writing and argues for a reading of Gao's writing as a phenomenon of "cultural translation": his adoption of Modernism in the 1980s is a translation of the European literary paradigm; and his attempt at postmodernist writing in the 1990s and 2000s is the effect of an exilic nihilism expressive of a diasporic subjectivity struggling to translate himself into his host culture. Thus Dr Yeung looks at Gao's works from a double perspective: in terms of their relevance both to China and to the West. Avoiding the common po...
