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Therapeutic Relevance and Mechanisms of Neuro-Immune Communication in Brain Injury
The brain is a critical organ with neuro-immune communication. The nervous system and immune system evolved to provide regulation of physiological homeostasis and protect against threats. Neuro-immune communication is correlated with physiological functions of various tissues and organs, and the internal environment balance. In brain trauma, the neural network is destroyed and the neuro-immune communication process is impaired. However, the research on this process is insufficient and limited. A thorough clarification of the cellular and molecular mechanisms of neuro-immune communication in brain injury is an essential necessary endeavor in the search for new therapeutic targets for brain injury. This Research Topic is devoted to the cellular and molecular mechanisms of neuro-immune communication in brain injury and on the meaningful exploration of how the nervous system regulates the immune system to promote neurofunctional recovery after brain injury.
Generative Adversarial Networks and Deep Learning
This book explores how to use generative adversarial networks in a variety of applications and emphasises their substantial advancements over traditional generative models. This book's major goal is to concentrate on cutting-edge research in deep learning and generative adversarial networks, which includes creating new tools and methods for processing text, images, and audio. A Generative Adversarial Network (GAN) is a class of machine learning framework and is the next emerging network in deep learning applications. Generative Adversarial Networks(GANs) have the feasibility to build improved models, as they can generate the sample data as per application requirements. There are various appl...
Basal Ganglia Circuits
The current basal ganglia model has been introduced 25 years ago and has settled the basis for most of our current understanding of Parkinson's disease. Despite the tremendous success of the model, a number of experimental evidences have been made available over the past 25 years and the "classical" basal ganglia model is somewhat obsolete. I believe that it would be possible to recruit a number of international leading experts that have generated new data on basal ganglia circuits and therefore a Research Topic of this kind would lead to the introduction of a fully updated basal ganglia model, incorporating all the new basal ganglia circuits that have been characterized over the past 25 years.
The CB2 Cannabinoid System: A New Strategy in Neurodegenerative Disorder and Neuroinflammation
The neurodegenerative disorders such as Parkinson’s disease (PD) or Alzheimer’s disease (AD) are the most common forms of dementia and no pharmacological treatments are to date available for these diseases. Indeed, the only used drugs are symptomatic and no useful to block the progression of the diseases. The lack of a therapeutic approach is also due to a lack of an early diagnosis. This Research Topic describes a new target that is involved in the firs step of these disorders and that can be useful for the treatment and the diagnosis of such pathologies: the cannabinoid receptor subtype 2 or CB2R. Indeed, CB2R is overexpressed in reactive microglia and activated astrocytes during neuroinflammation and thus their detection by PET probes can be an easily strategy for an early diagnosis of neurodegeneration. Moreover, CB2 agonists and inverse agonists displayed neuroprotective effects and they so can be candidated as new therapeutich drugs for the treatment of these pathologies. Therefore, the aim of this Research Topic is to show the great potential of CB2R ligands for the development of new tools/drugs for both the therapy and the diagnosis of neurodegeneration.
Britannica Book of the Year
Spine note : Events of 1997.
Handbook of Basal Ganglia Structure and Function
The Basal Ganglia comprise a group of forebrain nuclei that are interconnected with the cerebral cortex, thalamus and brainstem. Basal ganglia circuits are involved in various functions, including motor control and learning, sensorimotor integration, reward and cognition. The importance of these nuclei for normal brain function and behavior is emphasized by the numerous and diverse disorders associated with basal ganglia dysfunction, including Parkinson's disease, Tourette's syndrome, Huntington's disease, obsessive-compulsive disorder, dystonia, and psychostimulant addiction. The Handbook of Basal Ganglia provides a comprehensive overview of the structural and functional organization of the...
