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Animal Models of Acute Neurological Injuries
Despite numerous recent studies and exciting discoveries in the field, only limited treatment is available today for the victims of acute neurological injuries. Animal Models of Acute Neurological Injuries provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that currently jeopardizes advances in the field. Contributed by top experts and many original developers of the models, each chapter contains a step-by-step, proven procedure and visual aids covering the most commonly used animal models of neurological injury in order to highlight the practical applications of animal models rather than the theoretical issues. This intensive volume presents its readily reproducible protocols with great clarity and consistency to best aid neuroscientists and neurobiologists in laboratory testing and experimentation. Comprehensive and cutting-edge, Animal Models of Acute Neurological Injuries is an ideal guide for scientists and researchers who wish to pursue this vital course of study with the proficiency and precision that the field requires.
Neuronal and Vascular Plasticity
Galen in the 2nd century AD could be considered one of the earliest researchers who attempted to bridge the gap between basic science and clinical medicine. Galen is given initial credit for the recognition that vital organs of the body are exquisitely dependent upon the intact function of the circulatory system. The doctrines of Galenic physiology stated that blood was produced in the liver, flowed to the heart to obtain "vital spirits", and subsequently bathed the brain to gain "animal spirits". The "vital spirits" described by Galen were later disclosed to consist of oxygen. Oxygen was discovered independently by Schiele in Sweden and by Priestly in England. It was named oxygen (acid-form...
Animal Models of Acute Neurological Injury
Despite numerous recent studies and exciting discoveries in the field, only limited treatments are available today for the victims of acute brain and spinal cord injuries. Animal Models of Acute Neurological Injuries, Second Edition, provides a standardized methodology manual designed to eliminate the inconsistent preparations and variability that often inhibit advances in this specialized research field. In the 10 years since publication of the first edition of this book, some animal models have become obsolete, some have stood the test of time, and newer models have emerged to enhance our knowledge of acute neurological injuries. The second edition continues to offer the research community...
Brain Hypoxia and Ischemia
Brain Hypoxia and Ischemia explores the various aspects of cell death and survival that are crucial for understanding the basic mechanisms underlying brain hypoxia and ischemia. Chapters focus on a panorama of issues including the role of ion channels/transporters, mitochondria and apoptotic mechanisms, the roles of glutamate/NMDA, mechanisms in penumbral cells and the importance of intermittent hypoxia and gene regulation under these stressful conditions. The volume explores findings from both mammalian and invertebrate model systems and their applicability to human systems and diseases. Careful consideration is also given to differences in hypoxia and ischemia across development. This volume aims to increase the understanding of these mechanisms and to stimulate research on better diagnosis and treatment of diseases that afflict the brain and potentially other organs when O2 levels are dysregulated. Brain Hypoxia and Ischemia is designed for neuroscientists, clinicians and medical/graduate students for use in both basic research and clinical practice.
Silicon-Based Material and Devices, Two-Volume Set
This book covers a broad spectrum of the silicon-based materials and their device applications. This book provides a broad coverage of the silicon-based materials including different kinds of silicon-related materials, their processing, spectroscopic characterization, physical properties, and device applications. This two-volume set offers a selection of timely topics on silicon materials namely those that have been extensively used for applications in electronic and photonic technologies. The extensive reference provides broad coverage of silicon-based materials, including different types of silicon-related materials, their processing, spectroscopic characterization, physical properties, an...
Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems
A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.
Water in Lithium-Ion Batteries
This book reviews the impact of water content in lithium-ion batteries (LIBs) as well as the reactivity of anodes, cathodes and electrolytes with water and processes that provide water-resistance to materials in LIBs. Water in LIBs which were constructed with anode, cathode and organic electrolyte containing lithium salts can degrade the cell performance and seriously damage the materials present. However, because a small amount of water in cells contributes to the formation of the solid electrolyte interphase, complete removal of water from cells lowers the battery performance and increases costs due to removal of water from the battery materials. This book presents the optimal concentration of water for each battery material along with appropriate removal methods and water-scavengers which were developed recently to establish both high performance and lower costs. Moreover this book describes the development of anodes and cathodes prepared by aqueous process and aqueous LIBs in which aqueous electrolytes containing lithium salts are used as an electrolyte. This book will be useful not only for academic researchers but also for company researchers who deal with LIBs.
