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The Chinese Political Novel
"The political novel, which enjoyed a steep yet short rise to international renown between the 1830s and the 1910s, is primarily concerned with the nation’s political future. It offers a characterization of the present, a blueprint of the future, and the image of the heroes needed to get there. With the standing it gained during its meteoric rise, the political novel helped elevate the novel altogether to become the leading literary genre of the twentieth century worldwide. Focusing on its adaptation in the Chinese context, Catherine Vance Yeh traces the genre from Disraeli’s England through Europe and the United States to East Asia. Her study goes beyond comparative approaches and natio...
Research Advances of Tuberculosis Vaccine and its Implication on COVID-19
Tuberculosis (TB) is a global infectious disease caused by the Mycobacterium tuberculosis complex. The number of deaths caused by TB is second only to COVID-19. Therefore, vaccination plays an essential role in the prevention and control of TB. However, the efficacy of currently licensed TB vaccine, bacilli Calmette-Guérin (BCG), varies from 0%-80% in adults, and the protection only lasts for 10-15 years. Thus, there is an urgent need to develop advanced TB vaccines against TB infections.
Advances in Immunotherapeutic Approaches to Tuberculosis
We acknowledge the initiation and support of this Research Topic by the International Union of Immunological Societies (IUIS). We hereby state publicly that the IUIS has had no editorial input in articles included in this Research Topic, thus ensuring that all aspects of this Research Topic are evaluated objectively, unbiased by any specific policy or opinion of the IUIS.
Manchus and Han
China�s 1911�12 Revolution, which overthrew a 2000-year succession of dynasties, is thought of primarily as a change in governmental style, from imperial to republican, traditional to modern. But given that the dynasty that was overthrown�the Qing�was that of a minority ethnic group that had ruled China�s Han majority for nearly three centuries, and that the revolutionaries were overwhelmingly Han, to what extent was the revolution not only anti-monarchical, but also anti-Manchu? Edward Rhoads explores this provocative and complicated question in Manchus and Han, analyzing the evolution of the Manchus from a hereditary military caste (the �banner people�) to a distinct ethnic g...
Updates on Clinical and Molecular Epidemiology of Tuberculosis
Addressing the tuberculosis (TB) epidemic is crucial to reduce morbidity, mortality, and health-care burden. Cases of confirmed drug-resistant TB have almost doubled over the past decade. Drug resistance represents one of leading causes of death among TB patients and is responsible for approximately one-third of TB-related deaths worldwide, which is associated with TB recurrence and transmission. In recent years, the emerging molecular epidemiology methods have attributed to better TB management. For example, in many settings, studies using molecular epidemiology methods have demonstrated the recent transmission of Mycobacterium tuberculosis (M. TB) strains. However, the transmission pattern...
Precision Vaccinology for Infectious Diseases
The Human body is a vast network of interacting genes, proteins, and metabolites. These components, which may be considered host factors, change under disease, treatment or healthy condition. While treatment of many diseases depends on therapeutic drugs, vaccines remain the most effective long-term public health intervention to prevent infectious diseases. To date, vaccines have been developed to treat entire populations with little provision for predisposing individual host factor differences. However, the use and application of vaccines is facing multiple challenges with increasing numbers of vaccine non-responders and vaccine-relapsed individuals. The cause of this complication is partially due to host-factors. Another challenge is the adverse effects of vaccines in patients with primary immunodeficiency or autoimmune diseases, as well as vaccine-waning immunity in ageing populations, obese populations, or those with co-infection. To overcome these challenges, the solution may be the design, and formulation of precision vaccines, which are patient-specific.
Proceedings of The Fourth International Technical Symposium on Deepwater Oil and Gas Engineering
This book is a compilation of selected papers from the Fourth International Technical Symposium on Deepwater Oil and Gas Engineering & The Third International Youth Forum on Gas Hydrate, held in Qingdao, China in December 2021. The work focuses on the advancement of techniques for the deepwater oil and gas exploitation and natural gas hydrate exploitation. The book introduces new ideas for exploring deepwater oil and gas hydrate in a safe and efficient way. Advances of the natural gas hydrate pilot production in South China Sea, in oil and gas flow assurance and emerging technologies based on clathrate hydrate will be presented. It is a valuable resource for both practitioners and academics working in the field of deepwater oil and gas engineering.
