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Pharmacokinetic-Pharmacodynamic Model of Drugs and Their Pharmacokinetic Differences between Normal and Disease States
In the main frame of the above research topic, 16 contributions have been published including but not limited to the comparative pharmacokinetics between normal and disease status, the changes in the expression and function of drug-metabolizing enzymes and drug transporters in disease status and their related regulatory mechanisms, ADME/toxicity of drugs as well as their regulation, drug-drug interactions mediated by nuclear receptors, transporters and metabolic enzymes based on the methods and techniques of pharmacokinetics, transcriptomics, and metabolomics. However , the pharmacokinetic study is not only crucial in the development of new drugs, but also the study of pharmacokinetic-pharma...
Qualitative and Quantitative Analysis of Bioactive Natural Products 2018
Throughout most of history, medicinal plants and their active metabolites have represented a valuable source of compounds used to prevent and to cure several diseases. Interest in natural compounds is still high as they represent a source of novel biologically/pharmacologically active compounds. Due to their high structural diversity and complexity, they are interesting structural scaffolds that can offer promising candidates for the study of new drugs, functional foods, and food additives. Plant extracts are a highly complex mixture of compounds and qualitative and quantitative analyses are necessary to ensure their quality. Furthermore, greener methods of extraction and analysis are needed today. This book is based on articles submitted for publication in the Special Issue entitled “Qualitative and Quantitative Analysis of Bioactive Natural Products” that collected original research and reviews on these topics.
Can Traditional Chinese Medicines affect Endocrine Diseases via Effects on the Intestinal Flora?
Intestinal flora is a diversified and dynamic micro-ecosystem, whose structure and function have become a research hotspot in life sciences and medicine. The close relationship between intestinal flora and metabolic diseases has been verified by numerous studies. Traditional Chinese medicine (TCM) is used for disease prevention and treatment within China and is attracting attention and receiving more and more recognition from other countries all over the world. Consequently, the interaction of the two hotspots deserves further investigation. Although TCM has been put into practice for thousands of years, the study of its specific mechanism of action and related targets for the treatment of endocrine diseases is still at an exploratory stage. For TCM with oral administration as the main usage, the key targets of their active ingredients may be inextricably linked to the decomposition and metabolic effects of certain intestinal bacterium. All these hypotheses need to be tested further.
Religion, Ethnicity, and Gender in Western Hunan during the Modern Era
Suitable for use in courses on ethnic studies or gender studies Rethinks interaction between Han Chinese and non-Han cultures Considers how religion has adapted to the challenges of modern Chinese history Describes rituals and ritual specialists largely unknown to Western readers Combines historical and ethnographic methodologies
