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NSAIDs and Aspirin
This volume is a state-of-the art resource on the recent advances and clinical management of NSAIDs and aspirin. The text provides a thorough overview of NSAIDS and aspirin, reviewing such topics as pharmacology and mechanisms, clinical effects, and the safety and efficacy of these drugs. It also focuses on the effect of the drugs on the cardiovascular system and in the prevention of GI cancer. Practical recommendations for a safe prescription of NSAIDs are also included. Written by experts in the field, NSAIDs and Aspirin: Recent Advances and Implications for Clinical Management is a comprehensive text of great value to gastroenterologists, rheumatologists, cardiologists, oncologists, orthopedists, trauma and internal medicine specialists.
Bacterial Flora in Digestive Disease
Hundreds of bacterial species make up human gut flora. The intestine has at least 400 different species of bacteria totaling over 1012 organisms. Of these, 99% are anaerobic bacteria. The gastrointestinal tract is then exposed to countless numbers of bacterial species and foreign antigens and has embedded a unique and complex network of immunological and non-immunological mechanisms to protect the host from potentially harmful pathogens. Healthy individuals are generally tolerant to their own microbiota, but such tolerance is impaired in patients with both organic and functional gastrointestinal diseases. The advancement of the knowledge on microbial-gut interactions in health and disease ha...
Analysis and Curation of the Database of a Colo-Rectal Cancer Screening Program
Data collection in health programs databases is prone to errors that might hinder its use to identify risk indicators and to support optimal decision making in health services. This is the case, in colo-rectal cancer (CRC) screening programs, when trying to optimize the cut-off point to select the patients who will undergo a colonoscopy, especially when having insufficient offer of colonoscopies or temporary excessive demand. It is necessary therefore to establish ,Äúgood practice,Äù guidelines for data collection, management and analysis. With the aim of improving the redesign of a regional CRC screening program platform, we performed an exhaustive analysis of the data collected, proposing a set of recommendations for its correct maintenance. We also carried out the curation of the available data in order to finally have a clean source of information that would allow proper future analyses. We present here the result of such study, showing the importance of the design of the database and of the user interface to avoid redundancies keeping consistency and checking known correlations, with the final aim of providing quality data that permit to take correct decisions.
Bacterial Flora in Digestive Disease
Hundreds of bacterial species make up human gut flora. The intestine has at least 400 different species of bacteria totaling over 1012 organisms. Of these, 99% are anaerobic bacteria. The gastrointestinal tract is then exposed to countless numbers of bacterial species and foreign antigens and has embedded a unique and complex network of immunological and non-immunological mechanisms to protect the host from potentially harmful pathogens. Healthy individuals are generally tolerant to their own microbiota, but such tolerance is impaired in patients with both organic and functional gastrointestinal diseases. The advancement of the knowledge on microbial-gut interactions in health and disease ha...
Treatment and Prognostic Assessment of Liver Cirrhosis and Its Complications
About 2 million deaths worldwide annually are attributable to liver diseases. Among them, half die from cirrhosis and the other half from viral hepatitis and hepatocellular carcinoma. When patients with liver cirrhosis develop to the decompensated stage, a variety of complications will occur, such as ascites, spontaneous bacterial peritonitis, variceal bleeding, hepatic encephalopathy, hepatorenal syndrome, and jaundice, which will seriously affect the patient's quality of life with reduced survival time and increased socioeconomic burden. Therefore, early assessment and clinical management of cirrhosis and its complications are crucial for both clinicians and patients.
