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Management of Diabetic Foot Complications
​Public and political concern about the increasing prevalence of diabetes has prompted major concern about treatment of patients with the condition. Foot complications are some of the commonest causes of hospitalisation of people with diabetes and if not treated well often lead to amputation. There is evidence that 85% of these amputations can be prevented by better understanding of the problem and by multi-disciplinary teams working more effectively together. This has been recognised and NICE have recently published guidelines on diabetic foot complications as have Diabetes UK and NHS Diabetes. These have been successful in raising awareness of the problem but the local multi-disciplinary...
Musculoskeletal Ultrasound in Rheumatology Review
Point-of care ultrasound, or ultrasound performed and interpreted by the clinical in the clinic/office or at the bedside, has been rapidly expanding in use among multiple medical specialties. Musculoskeletal ultrasound has added value to clinical care to expedite diagnoses by visualizing mechanical versus inflammatory features and correlating these findings with patient’s symptoms. The use of power Doppler to assess for subclinical inflammation or active hyperemia has been a distinguishing use of ultrasound for rheumatologists. Accurate needle guidance with ultrasound for joint and tendon procedures has allowed expansion of procedures in the clinic and has been associated with less pain an...
Angiogenesis Assays
Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and...
Engineering Translational Models of Lung Homeostasis and Disease
Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, m...
Biomarker Tests for Molecularly Targeted Therapies
Every patient is unique, and the evolving field of precision medicine aims to ensure the delivery of the right treatment to the right patient at the right time. In an era of rapid advances in biomedicine and enhanced understanding of the genetic basis of disease, health care providers increasingly have access to advanced technologies that may identify molecular variations specific to an individual patient, which subsequently can be targeted for treatment. Known as biomarker tests for molecularly targeted therapies, these complex tests have the potential to enable the selection of the most beneficial treatment (and also to identify treatments that may be harmful or ineffective) for the molecu...
Encyclopedia of Ecology
The groundbreaking Encyclopedia of Ecology provides an authoritative and comprehensive coverage of the complete field of ecology, from general to applied. It includes over 500 detailed entries, structured to provide the user with complete coverage of the core knowledge, accessed as intuitively as possible, and heavily cross-referenced. Written by an international team of leading experts, this revolutionary encyclopedia will serve as a one-stop-shop to concise, stand-alone articles to be used as a point of entry for undergraduate students, or as a tool for active researchers looking for the latest information in the field. Entries cover a range of topics, including: Behavioral Ecology Ecologi...
Ecology, Virulence and Detection of Pathogenic and Pandemic Vibrio Parahaemolyticus
Vibrio parahaemolyticus is a gram negative, halophilic bacterium that occurs in the coastal and estuarine environments worldwide and is implicated in several cases of seafood-born gastroenteritis around the globe. However, not all strains of V. parahaemolyticus are pathogenic. Clinical isolates of V. parahaemolyticus most often produce either the thermostable direct haemolysin (TDH) or TDH-related haemolysin (TRH) encoded by tdh and trh genes, respectively. A pandemic clone of O3:K6 which was first detected in Kolkata (India), has been responsible for many outbreaks in Asia and the USA. With the emergence of pandemic clone of V. parahaemolyticus, this organism has assumed significance. Altho...
Technology-Based Health Promotion
This is the first textbook of its kind to offer students an introduction to best practices for using technology in health promotion programs. Integrating detailed case studies and interactive skill-building exercises throughout, this succinct and practical text teaches students to identify the most appropriate technology to meet their goals.
