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Towards translating research to clinical practice: Novel Strategies for Discovery and Validation of Biomarkers for Brain Injury
Traumatic brain injury (TBI) is a major cause of death and disability and one of the greatest unmet needs in medicine and public health. TBI not only has devastating effects on patients and their relatives but results in huge direct and indirect costs to society. Although guidelines for the management of patients have been developed and more than 200 clinical trials have been conducted, they have resulted in few improvements in clinical outcomes and no effective therapies approved for TBI. It is now apparent that the heterogeneity of clinical TBI is underlain by molecular phenotypes more complex and interactive than initially conceived and current approaches to the characterization, manageme...
Opiate Receptor Subtypes and Brain Function
This monograph is based upon papers and discussion from a technical review on opiate receptor subtypes and brain function which took place on September 26 and 27, 1985, at Bethesda, Maryland. The review meeting was sponsored by the Office of Science and the Division of Preclinical Research, National Institute on Drug Abuse.
