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Pharmaceutical companies are spending increasing amounts of money on drug discovery and development. Nevertheless, attrition rates in clinical development are still very high, and up to 90% of new compounds fail in clinical phase I - III trials, which is partially due to lack of clinical efficacy. This indicates a strong need for highly predictive in vitro and in vivo models. The "50th International Workshop of the Ernst Schering Research Foundation" focussed on "Animal Models of T Cell-Mediated Skin Diseases". Such animal models should have impact not only on inflammatory dermatoses but also on other inflammatory disorders due to their model character. The current volume summarises recent advances in animal research that are important for anti-inflammatory drug discovery.
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This book provides a reference guide in the field of dermatology, presenting and discussing its interface with public health. Dermatological diseases are extremely common in populations around the globe, and the systematization of knowledge about these dermatoses and their relationships with different epidemiological factors may help us to understand the challenges that governments and private institutions face and must try to overcome in order to improve global health. Undergraduate and graduate students, dermatologists and general practitioners who study and / or work in the area will find scientific support in this book, which is intended as a reference work for dermatological practice an...
The latest edition of the world’s leading dermatology textbook Rook’s Textbook of Dermatology, 10th Edition is the most definitive, comprehensive and illustrated reference work in dermatology worldwide. Fully updated by experts from around the world, the book highlights the latest key evidence-based developments in pathogenesis, diagnosis and treatment of skin disorders. A highly intuitive resource and invaluable clinical companion for both those training and those fully qualified in dermatology, other highlights of Rook’s Textbook of Dermatology, 10th Edition include: 1. Comprehensive review of essential basic science, skin biology and pharmacology 2. More than 3000 clinical illustrat...
Some people with psoriasis can also develop psoriatic arthritis, when the immune system attacks the joints as well, causing inflammation. Like psoriasis, psoriatic arthritis symptoms flare and subside, vary from person to person, and even change locations in the same person over time. Psoriatic arthritis can affect any joint in the body, and it may affect just one joint, several joints or multiple joints. For example, it may affect one or both knees. This issue will include articles on Genetic and Epigenetic aspects of psoriatic arthritis, Clinical features and diagnostic considerations in psoriatic arthritis, Natural history, prognosis and socioeconomic aspects of psoriatic arthritis, Etiology and pathogenesis of psoriasis and many more!
Practical and user-friendly, this is the ideal guide to the diagnosis and treatment of psoriasis, helping you navigate a logical management pathway through a complex maze of possibilities. Psoriasis is a cruel disease that can seriously affect the sufferer’s quality and length of life. It is also highly idiosyncratic, with features that vary greatly from patient to patient; this being mirrored in the highly variable response to treatment. It is increasingly recognized that psoriasis is not a discrete disease and that many patients suffer two or three comorbid conditions that can complicate the efforts of doctors treating patients. Psoriasis: Diagnosis and Management will provide dermatolog...
This is the third edition of the WHO's guidelines which are used by countries worldwide to set standards for the regulation of drinking water quality and effective approaches to water safety management. This revised edition has been updated to take account of recent developments in risk assessment and management. Topics discussed include: a framework for drinking water safety and discussion of the roles and responsibilities of different stakeholders, such as national regulators, water suppliers and independent surveillance agencies; guidance on microbial safety of drinking water through safety plans; new scientific information on chemicals, waterborne pathogens and individual chemical hazards of actual or potential concern. It also considers the application of the guidelines in specific circumstances, such as in emergencies and disasters, and to specific applications, such as bottled water. It also contains information on over 130 documents which substantiate or explain the content of the Guidelines, and on good practice guidance in achieving drinking-water safety.
ABC of Dermatology is the bestselling, practical guide for anyone involved in clinical dermatology. This fully illustrated book helps readers identify, recognise, treat, and manage the common dermatological conditions encountered in daily practice. The seventh edition has been revised and updated to incorporate current approaches to the management of skin disease, such as the use of new biological agents for treating inflammatory disease and tumours, and new chapters on cosmetic dermatology procedures, genital dermatology and cutting-edge advances in genetics and pathophysiology. Presents a practical approach to clinical dermatology that relates skin changes to specific skin conditions and u...
An essential guide to the proven automated sample preparation process While the measurement step in sample preparation is automated, the sample handling step is manual and all too often open to risk and errors. The manual process is of concern for accessing data quality as well as producing limited reproducibility and comparability. Handbook of Automated Sample Preparation for CG-MS and LC-MS explores the advantages of implementing automated sample preparation during the handling phase for CG-MS and LC-MS. The author, a noted expert on the topic, includes information on the proven workflows that can be put in place for many routine and regulated analytical methods. This book offers a guide t...