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Immunology and Psychiatry
Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
Feeding Behavior
Feeding Behavior: Neural and Humoral Controls discusses the role of well-known neural or humoral substrates. This book describes the neural and humoral mechanisms whose participation in the control of feeding is understudied. Organized into 11 chapters, this book starts with an overview of the ingestive behaviors of altricial mammals that mature through three transformations. This text then proceeds with a discussion of the separateness of the suckling and adult ingestion in laboratory rat pups, which revealed the existence of a system for ingestive behavior that is different from suckling. Other chapters discuss the physiological research on the feeding behavior, which is centered on the hypothalamus. This book examines as well the major brain region that is involved in the control of food intake. The final chapter examines the role of central cholecystokinin in the satiating effect of ingested food. Veterinary scientists and researchers will find this book extremely useful.
Emergencies in PSYCHIATRY in Low- and Middle-Income Countries
One of the cardinal facets of the delivery of mental healthcare is the attention given to emergency conditions-which is the focus of this book. The manifestations of psychiatric emergencies in low- and middle-income countries may be coloured by many factors, such as culture, the social context and religious belief systems. Hence, there is a need to not only understand these, but also formulate logical and acceptable forms of intervention. This book attempts to give the reader an overview of the kinds of psychiatric emergencies that can occur and the strategies employed to manage these in developing countries. The chapters on anxiety disorders, psychotic disorders, personality disorders and s...
Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders
This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
The Biology - Chemistry Interface
A tribute to the pioneering scientific work of Professor Koji Nakanishi, whose studies of natural products have effaced some of the conventional boundaries between biology and chemistry. It discusses an array of chromatographic separation methods and determination of structures on a microscale, analyzes bioassay-directed fractionation and other means of isolating biologically active compounds from plants and other sources, covers vital enzymes isolated from marine organisms such as algae, and more.
Chemistry and Brain Development
J. Folch-Pi Director of Scientific Research, McLean Hospital, Belmont, Mass., U.S.A. The development of the central nervous system is possibly the most significant aspect of the growth of a mammal from embryo to adulthood. The central nervous system is obviously the main repository not only of the species' inherited functional characteristics but also of the process of individuation. Whatever "engrams" constitute the basis of individual characteristics are laid down mainly in the central nervous system, and especially the brain, during its growth. The chemical aspect of this process IS clearly of great importance and the significance of its study should be self evident. Nevertheless, it is o...
Understanding Depression
This book, in two volumes, focuses on contemporary issues and dilemmas in relation to depression. The aim is to equip readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression, the clinical manifestations, and the development of more effective treatments. This second volume is devoted specifically to clinical and management issues. Readers will find detailed information on a wide range of frequently encountered and more complicated clinical presentations, with examination of risk factors and links to other conditions. Diagnostic aspects, including progress toward biological classification and the role of neuroimaging, are explored. Current trend...
Annual Reports in Medicinal Chemistry
Annual Reports in Medicinal Chemistry
The Handbook of Neuropsychiatric Biomarkers, Endophenotypes and Genes
Neuropsychiatric disorders such as schizophrenia, mood disorders, Alzheimer's disease, epilepsy, alcoholism, substance abuse and others are some of the most debilitating illnesses worldwide characterized by the complexity of causes, and lacking the laboratory tests that may promote diagnostic and prognostic procedures. Recent advances in neuroscience, genomic, genetic, proteomic and metabolomic knowledge and technologies have opened the way to searching biomarkers and endophenotypes, which may offer powerful and exciting opportunities to understand the etiology and the underlying pathophysiological mechanisms of neuropsychiatric disorders. The challenge now is to translate these advances int...
Societal Impacts on Information Systems Development and Applications
"This book has collected research from experts from around the world in a variety of sectors, in the form of case studies, frameworks, architectures, methodologies, and best practices to show the latest societal impacts on information systems development in its various applications"--Provided by publisher.
