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Neuroprogression in Psychiatric Disorders
In this volume, international experts critically review cutting-edge advances in neuroprogression research. The relevance of these findings to psychiatric and neurological disorders is clarified. Potential etiopathological mechanisms of neuroprogression are described in detail. Special emphasis is placed on the role of the immune system in stress and stress-related disorders and brain-immune interactions. The epigenetic consequences of adverse experiences in early childhood, which may prelude major psychiatric disorders, are also considered. Recent research has not only provided evidence of neuroprogression in psychiatric and neurological disorders, but has shown that pharmacologic intervent...
Inflammation in Psychiatry
Psychoimmunology is a rapidly maturing area of scientific endeavor that provides a compelling integrative link between the immune system and its response to stress and psychiatric illness. Stress initiates pathological changes by activating the immune and endocrine systems. Inflammation is at the core of the complex and interactive systems that both contribute to and result from psychopathology. Consequently, inflammation research advances our knowledge of the pathology of depression, schizophrenia, chronic fatigue syndrome, posttraumatic stress disorder and a host of co-morbid conditions, notably diabetes, cardiovascular disease and cerebrovascular disease. The possible mechanisms underlyin...
Immunology and Psychiatry
Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
Neuroinflammation, Gut-Brain Axis and Immunity in Neuropsychiatric Disorders
This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.
Psychophysiological States
Our understanding of psychophysiological states are now more broadly defined by the inclusion of the lateralized ultradian rhythms of the autonomic and central nervous systems (ANS and CNS) that play a key regulatory role in mind-body states. These neural rhythms are a unique step in the evolution of the nervous system that have mostly been ignored or missed in our understanding of physiology, mental activities, brain rhythms, and in the treatment of psychiatric disorders. The multivariate physiological experiments reviewed in this book provide a new “big picture for how the body’s major systems (ANS, CNS, neuroendocrine, cardiovascular, fuel-regulatory, gastrointestinal, immune) are reg...
Chemistry and Brain Development
J. Folch-Pi Director of Scientific Research, McLean Hospital, Belmont, Mass., U.S.A. The development of the central nervous system is possibly the most significant aspect of the growth of a mammal from embryo to adulthood. The central nervous system is obviously the main repository not only of the species' inherited functional characteristics but also of the process of individuation. Whatever "engrams" constitute the basis of individual characteristics are laid down mainly in the central nervous system, and especially the brain, during its growth. The chemical aspect of this process IS clearly of great importance and the significance of its study should be self evident. Nevertheless, it is o...
Inflammation-Associated Depression: Evidence, Mechanisms and Implications
Inflammation has invaded the field of psychiatry. The finding that cytokines are elevated in various affective and psychotic disorders brings to the forefront the necessity of identifying the precise research domain criteria (RDoCs) that inflammation is responsible for. This task is certainly the most advanced in major depressive disorders. The reason is that a dearth of clinical and preclinical studies has demonstrated that inflammation can cause symptoms of depression and conversely, cytokine antagonists can attenuate symptoms of depression in medical and psychiatric patients with chronic low grade inflammation. Important knowledge has been gained on the symptom dimensions that inflammation is driving and the mechanisms of action of cytokines in the brain, providing new targets for drug research and development. The aim of the book “Inflammation-Associated Depression” is to present this field of research and its implications in a didactic and comprehensive manner to basic and clinical scientists, psychiatrists, physicians, and students at the graduate level.
Advances in Psychiatry
This book is the newest edition on the series ‘advances in psychiatry’. The previous 3 volumes can be found online at http://www.wpanet.org/detail.php?section_id=10&content_id=660 . They were highly successful in covering a broad area of psychiatry from different perspectives and angles and by reflecting both specialized but also international and global approaches. This series have guaranteed quality therefore can be used by different scientific groups for teaching and learning and also as a means for fast dissemination of advanced research and transformation of research findings into the everyday clinical practice.
Platelets
2002 Best New Book in Medical Science - Professional/Scholarly Publishing Division of the Association of American Publishers Platelets is a comprehensive new textbook of 61 chapters and 1,100 pages (approx.) written by over 100 world leaders in the field. Platelets is a single definitive source of state-of-the-art knowledge about platelets. There has been no textbook that specifically and fully covers the entire field of platelet biology and clinical medicine. Platelets now fills this need. Platelets encompasses: platelet biology; platelet function testing; the role of platelets in disease; inherited and acquired disorders of platelet number and function; pharmacology of antiplatelet agents;...
Societal Impacts on Information Systems Development and Applications
"This book has collected research from experts from around the world in a variety of sectors, in the form of case studies, frameworks, architectures, methodologies, and best practices to show the latest societal impacts on information systems development in its various applications"--Provided by publisher.
