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Privileged Scaffolds in Medicinal Chemistry
One strategy to expedite the discovery of new drugs, a process that is somewhat slow and serendipitous, is the identification and use of privileged scaffolds. This book covers the history of the discovery and use of privileged scaffolds and addresses the various classes of these important molecular fragments. The first of the benzodiazepines, a class of drugs that is powerful for treating anxiety, may not have been discovered had it not been for a chance experiment on the contents of a discarded flask found during a lab clean-up. Some years later, scientists discovered that benzodiazepine derivatives were also effective in treating other diseases. This class of molecules was the first to be ...
No Matter, Never Mind
This international selection of 34 papers from the Tokyo '99 conference held at the United Nations University gives a valuable state of the art overview of consciousness research. Not only the recognized European and American approaches but also the distinguishing approaches from many Japanese researchers are presented. It will provide a world-wide audience with a comprehensive outlook for the remarkable potential contribution in the future scene of consciousness research.The Tokyo '99 declaration to promote scientists’ ethical warning against the thoughtless aiming of consciousness research at warfare is also included.(Series B)
Drugs for the Treatment of Parkinson’s Disease
With contributions by numerous experts
Science and Practice in Clinical Neurology
Science and Practice in Clinical Neurology illustrates the changing face of neurology by reviewing many recent developments in the field. Among the many topics covered are headache, movement disturbances, abnormalities of sensation, autonomic failure, multiple sclerosis, epilepsy, and molecular genetic approaches to neurological disease. The authors emphasize the pathophysiology of neurological disorders and make suggestions for diagnosis and treatment. They also discuss a number of new diagnostic tests, incuding PET scanning and motor-evoked potentials. The volume concludes with an authoritative overview of important new directions in neuroscience, concentrating particularly on the contribution of molecular genetics.
CNS Neurotransmitters and Neuromodulators
CNS Neurotransmitters and Neuromodulators: Dopamine is an indispensable single-volume resource for any researcher involved with dopamine in the central nervous system (CNS). Part of the CNS Neurotransmitters and Neuromodulators Series, it is destined to be the definitive reference work on this topic. This book is comprised of independently authored chapters dealing with biochemistry, molecular biology and localization of dopamine receptors and transporters, receptor interactions, growth factors, new antipsychotic drugs, and the neuroendocrinal and retinal functions of dopamine. The authors, an international group of well-known researchers from varied disciplines, have utilized the most up-to-date material in preparing their reviews. CNS Neurotransmitters and Neuromodulators: Dopamine is the perfect source for established researchers seeking the latest information or for students requiring an in-depth one-step introduction.
Micro-, Meso- and Macro-Dynamics of the Brain
This book brings together leading investigators who represent various aspects of brain dynamics with the goal of presenting state-of-the-art current progress and address future developments. The individual chapters cover several fascinating facets of contemporary neuroscience from elementary computation of neurons, mesoscopic network oscillations, internally generated assembly sequences in the service of cognition, large-scale neuronal interactions within and across systems, the impact of sleep on cognition, memory, motor-sensory integration, spatial navigation, large-scale computation and consciousness. Each of these topics require appropriate levels of analyses with sufficiently high temporal and spatial resolution of neuronal activity in both local and global networks, supplemented by models and theories to explain how different levels of brain dynamics interact with each other and how the failure of such interactions results in neurologic and mental disease. While such complex questions cannot be answered exhaustively by a dozen or so chapters, this volume offers a nice synthesis of current thinking and work-in-progress on micro-, meso- and macro- dynamics of the brain.
