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Rab GTPases now comprise a family of >63 members. They are emerging as the key hub element controlling the membrane architecture of eukaryotic cells. They are intimately involved in vesicle targeting and fusion in both the endocytic and exocytic pathways and direct the assembly and disassembly of protein complexes that include regulators (GEFs and GAPs), effectors (tethers/motors) and fusion components (SNAREs) that control membrane targeting and fusion. During the last 3 years the field has virtually exploded with the identification and characterization of many new Rab proteins and their effectors. Our understanding of how Rab GTPases control membrane function remains at its infancy. This v...
International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology, with articles addressing structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a worldwide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. - Authored by some of the foremost scientists in the field - Provides comprehensive reviews and current advances - Brings a fresh perspective to those conducting research in cell biology, molecular biology, biochemistry, biotechnology, plant biology, physiology, and microbiology, among others - Includes a wide range of perspectives on specific subjects - Valuable reference material for advanced undergraduates, graduate students, and professional scientists
Como hizo Cervantes con el Quijote, que puso la trama en manos de los dos personajes don Quijote y Sancho, explicando la multitud de aventuras por las tierras de la Mancha, Aragón y Barcelona, el autor de esta narrativa coloca la escena en manos de sus protagonistas, el Sr. Carter y el Sr. Átomo, quienes explican a detalle todas las teorías sobre el átomo desde su inicio hasta nuestros días, sin dejarse ningún tema apasionante para que el lector comparta y se sienta atraído por los últimos adelantos en el terreno de la Física y de la Química.\r Todo se lleva a cabo mediante una entrevista en la que el Sr. Carter es el entrevistador y el Sr. Átomo es el entrevistado, el cual responde a todas las preguntas que le formula el Sr. Carter para que las explicaciones sean entendidas por la inmensa mayoría de las personas.\r El autor también trata de llegar al lector explicándole en esta obra que la ciencia también tiene ese grado de humanidad que muchas veces la sociedad la trata de manera injusta ocultando los grandes beneficios que hemos tenido gracias a ella.
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The Blizzard is a quarterly football publication, put together by a cooperative of journalists and authors, its main aim to provide a platform for top-class writers from across the globe to enjoy the space and the freedom to write what they like about the football stories that matter to them. Issue Eight Contents ------------ Cyprus ------------ * The Wrong Side of the Border, by Jacob Steinberg—After decades of stalemate, Northern Cypriot football may be about to come in from the cold * The Hangover of War, by Cyrus Philbrick—Almost four decades after the Turkish invasion, the shadow of conflict hangs over the Nicosia derby -------------- Interview -------------- * Sepp Blatter, by Phil...
An investigation of the intrigue, politics and culture behind El Clásico - the hard-fought, long-running contest between two of the world's biggest football clubs - explaining the place sport's greatest rivalry has in Spanish life and the world of football.