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Toxin-Induced Models of Neurological Disorders
Tbis volume discusses and evaluates the use of neurotoxins to produce animal models of human neurodegenerative diseases. Tbe models presented use neuro toxins to induce some or most of the pathophysiological changes (including behavioral) that characterize the most studied motor neuron disorders and cogni tive disorders (dementia) in humans. Within the biomedical research community, there is little doubt about the utility of such models. But with increasing frequen cy, individuals concemed with animal rights question the validity of such models and argue that they actually produce no useful information for understanding or developing treatments for human disorders. Each of the chapters will ...
Ontogeny
This volume is devoted principally to the theme of behavioral develop ment. The study of ontogeny has attracted some of the most bitter and protracted controversies in the whole field of ethology and psychology. This is partly because the arguments have reflected more general and continuing ideological battles about nature and nurture. In the opening essay, Oppenheim shows how these debates have recurred in much the same form over the last century. His chapter also brings out a more worrying feature of such argument. He demonstrates that authors who are well known for their strongly held partisan views have written in much more balanced ways than is usually admitted. Although the ex cluded middle is familiar enough in academic argument, the dynamic tensions actually present in developing systems may be particularly prone to polarize debate about what is actually happening. This point is elegantly explored by Oyama in her essay on her concept of maturation.
The Memory System Of The Brain
The purpose of this book is to describe the memory system of the brain, taking into account all the levels of neural organization: molecule, cell, small network, and anatomical circuit. This synthetic approach is necessary for determining the real mechanisms among the potential ones, that is the neural bases of learning and memory in intact organisms functioning under normal conditions. For this purpose, data from molecular, cellular and behavioral neurobiology, neuropsychology, animal and human psychology, and neural modellization are comprehensively reviewed by leading specialists and brought together in an original synthesis.
Model Systems and the Neurobiology of Associative Learning
This volume contains a collection of papers written by former students, postdoctoral fellows, and colleagues of Richard Thompson and represent written versions of papers presented at the Festschrift symposium. The Festschrift provided an excellent opportunity for the participants to recount their memories and experiences of working with one of the leading figures in behavioral neuroscience, and to place their current research in the context of earlier research conducted in the Thompson laboratory. As a Festschrift volume, the various chapters contain numerous and sometimes very personal references to Richard Thompson's influence on the careers of the authors, as well as summaries of past and...
Environmental Neurotoxicology
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Progress in infancy Research
The Progress in Infancy Research Series is dedicated to the presentation of innovative and exciting research on infants, both human and animal. Each volume in the series is designed to stand alone and contains autonomous chapters which are based on high quality programs of research with infants. These chapters integrate the work of the authors with that of other experts working in the same or related areas. The authors wish to present high quality critical syntheses bearing on infant perception and sensation, learning and memory processes, and other aspects of development. This series will be a forum for the presentation of technological breakthroughs, methodological advances, and new integrations that might create platforms for future programmatic work on the complexities of infant behavior and development. Each volume in the series is dedicated to an outstanding investigator whose research has illuminated the nature of infant behavior and development, and whose contributions to the field have been of seminal importance.
Science of Olfaction
A book such as this one necessarily entails the effort of many individuals. Its first seed was a workshop in 1988 that one of us (K. L. C. ) designed and directed at the City University of New York Graduate Center as part of a series of conferences and workshops on topics in neuropsychology spon sored by the Institute for Research in Behavioral Neuroscience (IRBN). At that time, studies in the efficacy of olfaction as an alternative modality of stimulation in brain-injured adults were taking place at IRBN. The work shop helped to spark many new ideas among IRBN's staff, leading to various projects in clinical intervention, some of which are discussed in this volume. We soon discovered that c...
Reproductive and Developmental Toxicology
This timely resource offers extensive discussions on the pharmacological, environmental,endocrinological, and natural factors that alter reproductive or developmental processes-elucidating the effects of toxicants on mechanisms of reproduction. Describing biological actions common to both genders as well as gender-specific processes, Reproducti
Dopamine Receptors and Transporters
"Details the function, characterization, and physiology of various dopamine receptor/transporter systems and explores their role in etiology, diagnosis, and disease management."
