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This volume summarizes the state-of-the-art in the fast growing research area of modeling the influence of information-driven human behavior on the spread and control of infectious diseases. In particular, it features the two main and inter-related “core” topics: behavioral changes in response to global threats, for example, pandemic influenza, and the pseudo-rational opposition to vaccines. In order to make realistic predictions, modelers need to go beyond classical mathematical epidemiology to take these dynamic effects into account. With contributions from experts in this field, the book fills a void in the literature. It goes beyond classical texts, yet preserves the rationale of many of them by sticking to the underlying biology without compromising on scientific rigor. Epidemiologists, theoretical biologists, biophysicists, applied mathematicians, and PhD students will benefit from this book. However, it is also written for Public Health professionals interested in understanding models, and to advanced undergraduate students, since it only requires a working knowledge of mathematical epidemiology.
The future of oncology seems to lie in Molecular Medicine (MM). MM is a new science based on three pillars. Two of them are evident in its very name and are well known: medical science and molecular biology. However, there is a general unawareness that MM is firmly based on a third, and equally important, pillar: Systems Biomedicine. Currently, this term denotes multilevel, hierarchical models integrating key factors at the molecular, cellular, tissue, through phenotype levels, analyzed to reveal the global behavior of the biological process under consideration. It becomes increasingly evident that the tools to construct such complex models include, not only bioinformatics and modern applied statistics, as is unanimously agreed, but also other interdisciplinary fields of science, notably, Mathematical Oncology, Systems Biology and Theoretical Biophysics.
Since the parameters in dynamical systems of biological interest are inherently positive and bounded, bounded noises are a natural way to model the realistic stochastic fluctuations of a biological system that are caused by its interaction with the external world. Bounded Noises in Physics, Biology, and Engineering is the first contributed volume devoted to the modeling of bounded noises in theoretical and applied statistical mechanics, quantitative biology, and mathematical physics. It gives an overview of the current state-of-the-art and is intended to stimulate further research. The volume is organized in four parts. The first part presents the main kinds of bounded noises and their...
The construction of mathematical models is an essential scientific activity. Mathematics is associated with developments in science and engineering, but more recently mathematical modelling has been used to investigate complex systems that arise in other fields. This book demonstrates the application of mathematics to research topics in ecology and environmental science, health and medicine, phylogenetics and neural networks, theoretical chemistry, economics and management.
With chapters on free boundaries, constitutive equations, stochastic dynamics, nonlinear diffusion–consumption, structured populations, and applications of optimal control theory, this volume presents the most significant recent results in the field of mathematical oncology. It highlights the work of world-class research teams, and explores how different researchers approach the same problem in various ways. Tumors are complex entities that present numerous challenges to the mathematical modeler. First and foremost, they grow. Thus their spatial mean field description involves a free boundary problem. Second, their interiors should be modeled as nontrivial porous media using constitutive e...
This book collects papers presented at the International Conference on Mathematical Modelling and Computational Intelligence Techniques (ICMMCIT) 2021, held at the Department of Mathematics, The Gandhigram Rural Institute (Deemed to be University), Gandhigram, Tamil Nadu, India, from 10–12 February 2021. Significant contributions from renowned researchers from fields of applied analysis, mathematical modelling and computing techniques have been received for this conference. Chapters emphasize on the research of computational nature focusing on new algorithms, their analysis and numerical results, as well as applications in physical, biological, social, and behavioural sciences. The accepted papers are organized in topical sections as mathematical modelling, image processing, control theory, graphs and networks, and inventory control.
This book presents an Assessment of Physical Sciences and Engineering Advances in Life Sciences and Oncology (APHELION) by a panel of experts. It covers the status and trends of applying physical sciences and engineering principles to oncology research in leading laboratories and organizations in Europe and Asia. The book elaborates on the six topics identified by the panel that have the greatest potential to advance understanding and treatment of cancer, each covered by a chapter in the book. The study was sponsored by the National Cancer Institute (NCI) at the National Institute of Health (NIH), the National Science Foundation (NSF) and the National Institute of Biomedical Imaging and Bioengineering at the NIH in the US under a cooperative agreement with the World Technology Evaluation Center (WTEC).