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Metabolomics: From Fundamentals to Clinical Applications
This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.
Tools and Trends in Bioanalytical Chemistry
This textbook covers the main tools and techniques used in bioanalysis, provides an overview of their principles, and offers several examples of their application and future trends in diagnosis. Chapters from expert contributors explore the role of bioanalysis in different areas such as biochemistry, physiology, forensics, and clinical diagnosis, including topics from sampling/sample preparation, chemometrics in bioanalysis to the latest techniques used in the field. Particular attention is given to the recent advances in the application of mass spectrometry, NMR, electrochemical methods and separation techniques in bioanalysis. Readers will also find more about the application of microchip-based devices and analytical microarrays. This textbook will appeal to graduate/advanced undergraduate students in Chemistry, Biology, Biochemistry, Pharmacy, and Chemical Engineering. It is also a useful resource for researchers and professionals working in the fields of biomedicine and veterinary sciences, with clear explanations and examples of how the different bioanalytical devices are applied for clinical diagnosis.
Metallomics
This book covers the new Omics area, Metallomics. As Metallomics is intrinsically a transdisciplinary area, this book is authored by experts in the field on such diverse topics as Environmental, Nuclear, and Human Metallomics. Within these topics metals play important role, as being part of biomolecules, controlling different biochemical process, being signaling agents, being catalyst of biochemical reactions, among others. This volume demonstrates the importance of more investigation about metals and their interactions with biomolecules. As the knowledge in this field is growing and growing daily, then new challenges concerning studies involving Metallomics is appearing, such as comparative metallomics, speciation metallomics, real-time metallomics, new predictions of metals in biomolecules, metalloprotein databank expansion, interactions between metalloprotein-metalloprotein, among others.
Neuroproteomics as a Tool for Understanding Schizophrenia
Over the past decade, neuroproteomics has shed light on the molecular features of schizophrenia by depicting biological processes involved with its establishment, maintenance and treatment. These studies have also pointed to potential biomarkers applicable to diagnosis and medication monitoring. Edited by a leader in the field of neuroproteomics with contributions from subject experts, this new volume will address recent findings and compile evidence from difference perspectives—such as human samples, animal models, pluripotent stem cell-derived in vitro pre-clinical models—and provide findings to inform the development of innovative future treatment strategies. This volume will be useful for a broad audience of researchers and professionals, including biologists, neurologists, psychiatrists, analytical chemists, and pharmacists, among others.
Multi-Pronged Omics Technologies to Understand COVID-19
"COVID-19 and Omics Technologies" is a comprehensive, integrative assessment of recent information and knowledge collected on SARS-CoV-2 and COVID-19 during the pandemic based on omics technologies. It demonstrates how omics technologies could better investigate the infectious disease and propose solutions to the current concerns. The value of multi-omics technologies in understanding disease etiology and host response, discovering infection biomarkers and illness prediction, identifying vaccine candidates, discovering therapeutic targets, and tracing pathogen evolution is discussed in this book. These factors combine to make it a valuable resource to enhance understanding of both "Omics tec...
Ayahuasca as Liquid Divinity
Using the work of Bruno Latour, this book reimagines ayahuasca as liquid divinity, asking fundamental ontological questions that shift the focus from ayahuasca experiences to ayahuasca-based ritual practices that aim at cultivating relationships with more-than-human powers, described by Latour as "beings of transformation and religion."
Proteomic and Ionomic Study for Identification of Biomarkers in Biological Fluid Samples of Patients with Psychiatric Disorders and Healthy Individuals
This book presents an exploratory analysis based on proteomic and ionomics studies comparing the blood serum of patients with bipolar disorder (BD), healthy controls, patients with schizophrenia (SCZ), and patients with other disorders (OD) in order to identify biomarkers of BD. Bipolar disorder is a psychiatric condition that affects thousands of people worldwide. The absence of biomarkers for BD has resulted in misdiagnosis and ineffective treatment in some patients, causing additional health problems and high costs for health systems. As such, this book evaluates various strategies for sample preparation for proteomic and ionomic studies in order to simplify complex serum samples and allow the quantification of chemical species (proteins and metal ions), which are potential candidates for BD biomarkers. In addition, it describes the development of a new membrane-based methodology for extracting urine proteins to be used in biomarker discovery.
Projeto Zavtra
Uma crise financeira mundial se instaura. Proíbe-se a circulação de alguns medicamentos. O número de suicídios aumenta bruscamente. Países se unem e fundam a SUCOMB – Suicide Combat, organização que visa incentivar projetos de combate ao suicídio. Entre as entidades associadas estão a Zavtra, com sede na Rússia, a inglesa Faith Healers e a Les Gardiens, da França. O psicólogo Aleksey Petrovin ingressa na Zavtra, uma organização russa com misteriosos métodos de tratamento a pacientes que tentaram suicídio. Nesse ínterim, um padrão no perfil dos pacientes chama a atenção de auditores da SUCOMB, da polícia e da própria Zavtra: todos os pacientes são admiradores da cantora Caligo, um ícone do pop-rock da atualidade. O time da Zavtra entra em ação, investigando qualquer relação entre as músicas com o crescente número de suicídios; iniciando-se uma trama policial envolvendo mortes misteriosas, romance, perseguições, muito suspense e uma pitada de humor negro. Desvende essa conspiração e compreenda o real significado do Projeto Zavtra.
Psiconautas
Em Psiconautas, fruto de uma extensa pesquisa, Marcelo Leite conta a história das principais drogas psicodélicas, desde sua descoberta no século 20 até o uso medicinal revolucionário que vem sendo feito de cada uma delas atualmente. Mesclando relatos da própria experiência com várias dessas substâncias ao perfil dos principais pesquisadores da área, muitos deles brasileiros, Leite oferece um panorama completo do chamado renascimento psicodélico, desfaz mitos e aponta para conquistas científicas há pouco tempo impensáveis, como tratamento para a dependência química, a depressão e a síndrome do estresse pós-traumático, entre outros benefícios ainda sendo pesquisados. O livro recebeu um prefácio de Sidarta Ribeiro que, junto a Luís Fernando Tófoli, Stevens "Bitty" Rehen e Dráulio de Araújo, compõe o grupo dos psiconautas brasileiros que guiaram Marcelo em suas explorações.
