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understanding the mechanisms involved in liver regeneration is of crucial importance for clinical medicine, not only regarding carcinogenesis and diabetes treatment, but also for the use of stem cells for cell therapy and liver surgery. This graduate-level text provides an overview of the current state of knowledge of the molecular mechanisms of liver regeneration. Hepatic stem cells are introduced and the important players involved in regeneration such as oval cells, bone marrow and stellate cells are reviewed. The cell signaling pathways that initiate liver regeneration and regulate the switch between proliferation and apoptosis are presented and the role of liver stem cells in tumorigenesis is discussed. The book also treats the epigenetic regulation of liver stem cells and the roles of inflammation and angiogenesis in liver regeneration. This compact overview of the fascinating regenerative capacity of the liver will be of interest to graduate students and post-docs in molecular biology, biochemistry and medicine.
How does the South African government react to changes in its debt position? In investigating the question, this paper estimates fiscal reaction functions using various methods (OLS, VAR, TAR, GMM, State-Space modelling and VECM). The paper finds that since 1946 the South African government has ran a sustainable fiscal policy, by reducing the primary deficit or increasing the surplus in response to rising debt. Looking ahead, the paper considers the use of fiscal reaction functions to forecast the debt/GDP ratio and gauging the likelihood of achieving policy goals with the aid of probabilistic simulations and fan charts.
This book is an essential contribution to the transdisciplinary field of critical design studies. The essays in this collection locate design at the center of a series of interrelated planetary crises, from climate change, nuclear war, and racial and geopolitical violence to education, computational culture, and the loss of the commons. In doing so, the essays propose a range of needed interventions in order to transform design itself and its role within the shifting realities of a planetary crisis. It challenges the widely popular view that design can contribute to solving world problems by exposing how this attitude only intensifies the problems we currently face. In this way, the essays c...
Microgrid technology is an emerging area, and it has numerous advantages over the conventional power grid. A microgrid is defined as Distributed Energy Resources (DER) and interconnected loads with clearly defined electrical boundaries that act as a single controllable entity concerning the grid. Microgrid technology enables the connection and disconnection of the system from the grid. That is, the microgrid can operate both in grid-connected and islanded modes of operation. Microgrid technologies are an important part of the evolving landscape of energy and power systems. Many aspects of microgrids are discussed in this volume, including, in the early chapters of the book, the various types...
Microgrids and Active Distribution Networks offer a potential solution for sustainable, energy-efficient power supply to cater for increasing load growth, supplying power to remote areas, generation of clean power and reduction in emission of greenhouse gases & particulates as per Kyoto protocol.
In its pursuit to equip the reader with a basic knowledge of Islamic economics, this book divulges the micro-foundations of the discipline, and highlights the predominant schools of thought that exist in the field. It explains, in simple terms, what Islamic economics entails and how it can be studied as a science in relation to the Holy Quran, the Sunnah and the Islamic intellectual tradition based on these two sources. The book familiarizes the reader with knowledge of the basic maxims of the discipline. It then establishes the arguments that are presented by the proponents of religion-based economics, specifically Islam, and apprises readers about the aforementioned schools as they exist. ...
Presenting a blend of applied and fundamental research in highly interdisciplinary subjects of rapidly developing areas, this book contains contributions on the frontiers and hot topics of laser physics, laser technology and laser engineering, and covers a wide range of laser topics, from all-optical signal processing and chaotic optical communication to production of superwicking surfaces, correction of extremely high-power beams, and generation of ultrabroadband spectra. It presents both review-type contributions and well researched and documented case studies, and is intended for graduate students, young scientist, and emeritus scientist working/studying in laser physics, optoelectronics, optics, photonics, and adjacent areas. The book contains both experimental and theoretical studies, as well as combinations of these two, which is known to be a most useful and interesting form of reporting scientific results, allowing students to really learn from each contribution. The book contains over 130 illustrations.