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Pathobiology of the Human Atherosclerotic Plaque
Seymour Glagov The last meeting, devoted exclusively to an examination of the atherosclerotic plaque, took place in Chicago 25 years ago under the joint auspices of the Council on Arteriosclerosis of the American Heart Association and the Chicago Heart Association. The proceedings were published subsequently in a volume entitled "Evolution of the Atherosclerotic Plaque", edited by Richard J. Jones (1). Both experimental and human lesions were considered and several provocative new approaches to the disorder were discussed. The electron microscope was being applied systematically to the study of blood vessels at that time, so that details of the infrastructure and cellular composition of the artery wall and of atherosclerotic lesions were presented in some detail. There was, as one result of these explorations, considerable discussion of morphologic evidence suggesting that the principal cell involved in the atherogenic process was neither the fibroblast nor the macrophage, as had been supposed, but the smooth muscle cell. In particular, the findings indicated that this cell could incorporate lipid and become a foam cell.
The Complete Guide to Fasting
Thousands of books have been written about the latest and greatest diets that will help people lose weight and improve health. But a key element in any successful nutritional health program is a tried-and-true method that most people haven't thought about. This ancient secret is fasting. In The Complete Guide to Fasting, he has teamed up with international bestselling author and veteran health podcaster Jimmy Moore to explain what fasting is really about, why it's so important, and how to fast in a way that improves health.
Tobacco Smoking and Atherosclerosis
Atherosclerosis is the principal underlying cause of cardiovascular and cerebrovascular disease in people of the Western world. Cigarette smoking has been implicated in both the initiation and exacerbation of the atherosclerotic process. Data to support this implication derives primarily from epidemiologic studies where the relationship between the incidence of atherosclerosis in people who smoke cigarettes has been shown to have a strong correlation. There are few well established explanations for this phenomenon, and basic molecular, biochemical, and cellular mechanisms associated with smoking and the development of atherosclerosis remain both undefined and virtually unexplored. Even the e...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
The Biological Consequences of Socioeconomic Inequalities
Social scientists have repeatedly uncovered a disturbing feature of economic inequality: people with larger incomes and better education tend to lead longer, healthier lives. This pattern holds across all ages and for virtually all measures of health, apparently indicating a biological dimension of inequality. But scholars have only begun to understand the complex mechanisms that drive this disparity. How exactly do financial well-being and human physiology interact? The Biological Consequences of Socioeconomic Inequalities incorporates insights from the social and biological sciences to quantify the biology of disadvantage and to assess how poverty gets under the skin to impact health. Draw...
Case Studies in Lipid Management
John Betteridge, Professor of Medicine at the Middlesex Hospital in London is one of the world's leading lipidologists and diabetologists. Professor Betteridge has bought together a definitive collection of 35 study cases written by opinion leaders in the field of lipid management. Each case is a highly informative study based on each contributor's
Atherosclerosis V
The objective of the program committee of the Fifth International Symposium on Atherosclerosis was to bring together experts in many disciplines to broaden the scope of the attack on this disease and to foster interaction. Our hope was that such interaction would accelerate the eradication of the disease. The symposium achieved that objective and con tinued the tradition of the previous symposia in providing a forum for summaries of recent research developments in the study, treatment and prevention of atherosclerosis. The leading authorities and researchers in this field and in the related areas of interest have presented the newest information, concepts and ideas that have evolved in the p...
Atherosclerosis IV
The presence of monotypism in thick atherosclerotic lesions of black females with G-6-PD mosaicism first reported by the Benditts (1973) has been confirmed in two other laboratories. However, we believe that it is premature to conclude that the finding of monotypism necessarily indicates monoclonal origin of athero sclerotic lesions. We have suggested two alternative explanations for the obser vation of monotypism which we believe must be shown to be invalid before accept ing monoclonal origin as the only plausible way to account for the observed G-6-PD monotypism. One of these two alternatives relates to clonal heterogeneity of cell growth potential, i. e. , during the course of progressive...
