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Stereochemical Aspects of Drug Action and Disposition
This book aims to guide and inspire drug researchers as they enter the 21st century. Stereochemistry is an essential dimension in pharmacology and should be understood as such by all drug researchers whatever their background. When used as probes or medicines, stereoisomeric drugs offer invaluable insights or innovative therapeutic strategies. The book spans the subject from the molecular to the clinical. The first section on chemical aspects contains chapters on chemical synthesis, analysis, natural products, chiral stability (racemezation) and physical properties. The second section is on experimental pharmacology, with chapters on drug-receptor interactions, chiral recognition, ion channels, and molecular toxicology. The third section focuses on drug disposition, with chapters on absorption, distribution, protein binding, metabolism and elimination. The final section is dedicated to regulatory and clinical aspects.
Therapeutic Drug Monitoring
Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on...
Ohio's Lake Erie Wineries
Ohio's Lake Erie wineries and vineyards are rooted in tradition. European immigrants settled on the Lake Erie islands and nearby shoreline in the mid-1800s, and the grape industry flourished in Ohio into the early 20th century. Industrialization from Cleveland to Toledo swallowed up prime growing property along the lakeshore, but many farms continued to grow grapes. During Prohibition, wine making went underground. When it ended, restaurant owners bottled their own fortified wines and some of the wineries started mass producing wine with new equipment. The wines of Ohio, like those all over the eastern United States, were mostly sweet and made from native labrusca grapes. In the 1960s, Ohio's serious winemakers learned how to cultivate European-style vinifera grapes along Lake Erie's shore and on the islands. Chardonnay and cabernet sauvignon grapes now grow alongside Concord and Catawba. Today, more than 40 wineries stretch across northern Ohio.
Hypertrophic Cardiomyopathy
First described in 1907 by Schicke but recognized as a clinical entity only as recently as 1958, when Teare published the pathologic findings in patients with hypertrophic cardiomyopathy (HeM), an explosion of knowledge about this fascinating disease has occurred, which has caused a profound evolution of our understanding of its broad pathophysiologic and clinical spectrum. Progress has been particularly rapid in the past few years when M-mode echocardiography, and more recently 2-dimen sional echocardiography have been applied to the study ofHCM. In addition to new insights as to what the disease is, there has been enormous progress concerning its treatment, with the application of beta-adrenergic blocking agents and surgical relief of left ventricular outflow tract obstruction. Although these approaches have led to great strides in the symptomatic control of the disease, many patients' symptoms have remained refactory to medical and surgical therapy. Most discouragingly, sudden death still occurs, even in patients on large doses of beta-blocking agents and in patients who have had surgical relief of left ventricular outflow tract obstruction.
Eger Stars
Egri Csillagok ("Eger Stars") by Géza Gárdonyi, one of the most recognized and widely read books in Hungarian literature, was first published in 1899. The historical novel is set in a Hungary defeated by the Ottoman Turks at Mohács in 1526 and torn apart by rival kings, the Hungarian King John Zápolya with his base in Transylvania and the Austrian Hapsburg Ferdinand. The novel reaches its climax with the successful Hungarian defense of Eger Castle in 1552 by some 2,000 defenders against an Ottoman army numbering over 40,000.
Information Resources in Toxicology
History: -- K.D. Watson, P. Wexler, and J. Everitt. -- Highlights in the History of Toxicology. -- Selected References in the History of Toxicology. -- A Historical Perspective of Toxicology Information Systems. -- Books and Special Documents: -- G.L. Kennedy, Jr., P. Wexler, N.S. Selzer, and L.A. Malley. -- General Texts. -- Analytical Toxicology. -- Animals in Research. -- Biomonitoring/Biomarkers. -- Biotechnology. -- Biotoxins. -- Cancer. -- Chemical Compendia. -- Chemical--Cosmetics and Other Consumer. -- Products. -- Chemical--Drugs. -- Chemical--Dust and Fibers. -- Chemical--Metals. -- Chemicals--Pesticides -- Chemicals--Solvents. -- Chemical--Selected Chemicals. -- Clinical Toxicology. -- Developmental and Reproductive Toxicology. -- Environmental Toxicology--General. -- Environmental Toxicology-- Aquatic. -- Environmental Toxicology--Atmospheric. -- Environmental Toxicology--Hazardous Waste. -- Environmental Toxicology--Terrestrial. -- Environmental Toxicology--Wildlife. -- Ep ...
Oral Health in South Australia
Oral health in South Australia 2008 provides a comprehensive summary of the oral health of South Australian residents. This publication was developed from a range of surveys conducted by the Australian Research Centre for Population Oral Health (ARCPOH) and administrative data provided by state dental services.
Pharmacogenetics: Making cancer treatment safer and more effective
Chemotherapy has made a dramatic difference to improved survival in patients with cancer. However, not all patients respond and some experience serious side effects. "Pharmacogenetics: Making cancer treatment safer and more effective" is an up to date summary of the exciting new field of how genetic testing can tailor more effective prescription in oncology. It is targeted at oncologists and professionals involved in the treatment of patients with cancer. It provides a core background in genetics and pharmacological principles before providing chapters from acknowledged experts in the field on genetic tests in specific cancer types, including breast, bowel and lung cancer. Clinical cases are used to illustrate the practical application of this knowledge. Chapters on ethics, health economics and the industry aspects of pharmacogenetics set out the challenges and opportunities afforded by this new science.
