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The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained through the years. The identification of endogenous opioids and their receptors (mu, delta, kappa, and nociceptin), molecular cloning, and the elucidation of the crystal structures of opioid receptors represent key milestones in opioid research. The opioid system modulates numerous pharmacological responses, with therapeutic (i.e., analgesia) and detrimental side effects (i.e., addiction). The medical use and misuse of opioids have dramatically increased, leading to the 21st century opioid crisis. This book presents recent developments in opioid drug discovery, specifically in the medicinal chemistr...
Deutsches und polnisches Strafrecht sind sich in vieler Hinsicht ahnlich, beispielhaft erkennbar ist dies daran, dass die Strafrechtswissenschaft in beiden Landern dieselben Systembegriffe verwendet. Unterschiede gibt es gleichwohl, so hinsichtlich positiver wie negativer Generalpravention in der Strafzumessung im Allgemeinen und bezuglich der Abschreckungspravention im Speziellen. In Deutschland unter strengen Voraussetzungen bei der Begrundung der Strafhohe zugelassen, ist die Abschreckungspravention in Polen schlechthin verboten. Die Dissertation erlautert Hintergrunde und Anwendungsfelder der Generalpravention und arbeitet anhand der Rechtsprechung verschiedene Fallgruppen heraus.
Family Law Arbitration is a guide to arbitration in family matters both financial and in respect of children. It sets out: - what is meant by arbitration - the process - the purpose - its benefits - important cases including arbitration decisions confirmed in the High Court It gives practitioners and lay individuals an understanding of family law arbitration, how it works in family matters and what can be expected when an arbitration proceeds, showing both the lawyers involved and the client all they need to know in terms of practice and procedure. There have been a number of developments since publication of the second edition in 2017 including numerous cases and revised practice guidance o...
The Lloyd’s Register of Yachts was first issued in 1878, and was issued annually until 1980, except during the years 1916-18 and 1940-46. Two supplements containing additions and corrections were also issued annually. The Register contains the names, details and characters of Yachts classed by the Society, together with the particulars of other Yachts which are considered to be of interest, illustrates plates of the Flags of Yacht and Sailing Clubs, together with a List of Club Officers, an illustrated List of the Distinguishing Flags of Yachtsmen, a List of the Names and Addresses of Yacht Owners, and much other information. For more information on the Lloyd’s Register of Yachts, please click here: https://hec.lrfoundation.org.uk/archive-library/lloyds-register-of-yachts-online
The Lloyd’s Register of Yachts was first issued in 1878, and was issued annually until 1980, except during the years 1916-18 and 1940-46. Two supplements containing additions and corrections were also issued annually. The Register contains the names, details and characters of Yachts classed by the Society, together with the particulars of other Yachts which are considered to be of interest, illustrates plates of the Flags of Yacht and Sailing Clubs, together with a List of Club Officers, an illustrated List of the Distinguishing Flags of Yachtsmen, a List of the Names and Addresses of Yacht Owners, and much other information. For more information on the Lloyd’s Register of Yachts, please click here: https://hec.lrfoundation.org.uk/archive-library/lloyds-register-of-yachts-online
This book concerns building an idealized image of the society in which the Holocaust occurred. It inspects the category of the bystander (in Polish culture closely related to the witness), since the war recognized as the axis of self-presentation and majority politics of memory. The category is of performative character since it defines the roles of event participants, assumes passivity of the non-Jewish environment, and alienates the exterminated, thus making it impossible to speak about the bystanders’ violence at the border between the ghetto and the ‘Aryan’ side. Bystanders were neither passive nor distanced; rather, they participated and played important roles in Nazi plans. Start...
Molecular Docking for Computer-Aided Drug Design: Fundamentals, Techniques, Resources and Applications offers in-depth coverage on the use of molecular docking for drug design. The book is divided into three main sections that cover basic techniques, tools, web servers and applications. It is an essential reference for students and researchers involved in drug design and discovery. - Covers the latest information and state-of-the-art trends in structure-based drug design methodologies - Includes case studies that complement learning - Consolidates fundamental concepts and current practice of molecular docking into one convenient resource