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The Cellular Response to the Genotoxic Insult
Genotoxic carcinogens can lead to DNA mutations with the potential to cause cancer. Typically, a series of mutation events are needed before malignancy occurs so a single, small exposure may not result in disease. Also, cells have an armoury of defence mechanisms which, to a degree, counter the effects of mutagens. Distinguishing the point at which exposure to a carcinogen increases mutation rates beyond the background level is challenging. In fact, there is now general agreement that, for genotoxic carcinogens, no specific threshold can be identified. However, NOAELs (No Observed Adverse Effect Levels) may be used in the process of establishing a dose-response relationship. These denote the...
The Virus and the Host
Learn how to take control of your health—and decrease susceptibility to infectious viral disease before it strikes. There will almost certainly be more pandemics in our future. Yet, during the coronavirus crisis, not a single major public health official took the simple step of telling Americans what we all need to hear: Robust good health—healthy immunity, low inflammation, low toxic burden, and freedom from stealth infection and chronic disease—is our best defense against infectious viral disease. Of course, it’s not that simple. The way our bodies interact with infectious disease is complicated—both a function of the “germ” and the “terrain”—the virus and the host. In ...
Vegas Concierge
Vegas Concierge tells the tale of domestic sex trafficking in America through the riveting inside story of a decade-long investigation into sex trafficking, police corruption, and hip-hop music in Sin City. A layered saga spanning more than a decade, Vegas Concierge moves from the luxury hotel rooms of the Las Vegas Strip to the inner offices of the Las Vegas police and some of Nevada’s biggest news organizations. Using public and private records as well as exclusive, first-person accounts from primary sources, this book shows how prostitutes and pimps ply their trade, how law enforcement agencies trip up and their investigations become compromised, and how self-interest corrupts news organizations and the corridors of power. More than anything, this book examines the disregard American society has towards sex trafficking victims. Vegas Concierge ties together intersecting worlds via a diverse array of characters who played roles in this sordid tale about police corruption and incompetence, the price of celebrity, and the culture of Sin City.
Predictive Toxicology
Ein moderner integrierter Ansatz für die Sicherheitsprüfung in der Arzneimittelentwicklung: Dieses Praktikerbuch behandelt In-silico- und In-vitro-Methoden sowie den Einsatz von Biomarkern, mit denen bei kleinen Arzneistoffmolekülen und Biologika frühzeitig und zuverlässig Toxizitäts-Screenings durchgeführt werden können.
The Purdue Alumnus
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Angela Hutchinson Hammer
"A true daughter of the West, Angela, born in a tiny mining hamlet in Nevada, came to the territory of Arizona at the age of twelve. Betty Hammer Joy weaves together the lively story of her grandmother's life by drawing upon Angela's own prodigious writing and correspondence, newspaper archives, and the recollections of family members. Her book recounts the stories Angela told of growing up in mining camps, teaching in territorial schools, courtship, marriage, and a twenty-eight-year career in publishing and printing.".
