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Intracellular cell signaling is a well understood process. However, extracellular signals such as hormones, adipokines, cytokines and neurotransmitters are just as important but have been largely ignored in other works. Aimed at medical professionals and pharmaceutical specialists, this book integrates extracellular and intracellular signalling processes and offers a fresh perspective on new drug targets.
In 1908, Arthur Wavell left England to begin his journey to Mecca, determined to find out more about Arab customs with a view to future adventures into the unexplored interior of Arabia. Due to the suspicion a westerner would arouse, and the fact that unbelievers were forbidden by the authorities to enter Mecca, he undertook his pilgrimage in disguise. His journey to Damascus, Medina, and finally Mecca with his two companions-a Swahili Muslim from Mombasa and an Arab from Aleppo-is detailed in the first part of this reprint, which was originally published in 1912. Additionally, the book describes Wavell's abortive attempt to explore south central Arabia, including his capture and expulsion from Yemen by the Turkish authorities. A Modern Pilgrim in Mecca, now back in print, will be of great value to historians, to scholars of the region or period, and to armchair adventurers.
A meditation on the relationship between pop star and pop fan, this intriguing and thoroughly entertaining epistolary novel tracks a 30-year, one-way correspondence from devoted music fan Gary to rock icon David Bowie. Beginning as an angst-ridden teenager, Gary writes letters to Bowie, sharing his thoughts on everything from Ziggy Stardust and Glass Spiders to his boarding school days and adult life as a husband and father.
It's no secret that our planet—and the delicate web of ecosystems that comprise it—is in crisis. Environmental threats such as climate change, pollution, habitat loss, and land degradation threaten the survival of thousands of plant and animal species each day. In 100 Heartbeats, conservationist and television host Jeff Corwin provides an urgent, palpable portrait of the wildlife that is suffering in silence and teetering on the brink of extinction. From the forests slipping away beneath the stealthy paws of the Florida panther, to the giant panda's plight to climb ever higher in the mountains of China in search of sustenance, to the brutal poaching tactics that have devastated Africa's ...
Although a number of edited collections deal with either the languages of the world or the languages of particular regions or genetic families, only a few cover sign languages or even include a substantial amount of information on them. This handbook provides information on some 38 sign languages, including basic facts about each of the languages, structural aspects, history and culture of the Deaf communities, and history of research. This information will be of interest not just to general audiences, including those who are deaf, but also to linguists and students of linguistics. By providing information on sign languages in a manner accessible to a less specialist audience, this volume fills an important gap in the literature.
Henrik Johan Ibsen was a major 19th-century Norwegian playwright, theatre director, and poet. He is often referred to as "the father of realism" and is one of the founders of Modernism in theatre. Ibsen's later work examined the realities that lay behind many facades, revealing much that was disquieting to many contemporaries. It utilized a critical eye and free inquiry into the conditions of life and issues of morality. The poetic and cinematic early play Peer Gynt, however, has strong surreal elements. Ibsen is often ranked as one of the truly great playwrights in the European tradition. Richard Hornby describes him as "a profound poetic dramatist-the best since Shakespeare". He is widely regarded as the most important playwright since Shakespeare. He influenced other playwrights and novelists such as George Bernard Shaw, Oscar Wilde, Arthur Miller, James Joyce, Eugene O'Neill and Miroslav Krleza. Ibsen was nominated for the Nobel Prize in Literature in 1902, 1903 and 1904.
Architectural discourse today is characterized by an overlapping conversation between architects and academics, teachers and students, theorists and practitioners. Crib Sheets is a guide - a crib - to twenty-two of those buzzwords (diagram; extreme form; autonomy and the generic), framing contemporary currents and trajectories.
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