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New insights into innate immune cell-based immunotherapies in cancer
  • Language: en
  • Pages: 256
Emerging Concepts on the NKG2D Receptor- NKG2D Ligand Axis in Health and Diseases
  • Language: en
  • Pages: 212
Progress Report
  • Language: en
  • Pages: 580

Progress Report

  • Type: Book
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  • Published: 1984
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  • Publisher: Unknown

None

The Second Life of Natural Killer (NK) Cells
  • Language: en
  • Pages: 118

The Second Life of Natural Killer (NK) Cells

Natural Killer (NK) cells are innate lymphocytes, now recognized as members of a larger family of “Innate lymphoid cells” (ILCs). Both murine and human NK cells are well characterized effector cells with cytotoxic as well as cytokine production ability which mainly react in response to microbial and cell stress stimuli, thus playing a central role in the defense against pathogen infection, in tumor surveillance and in regulating immune homeostasis. Despite these established concepts, our understanding of the complexity of NK cells, also in view of their developmental and functional relationship with other ILC subsets, is only recently emerging. This Research Topic highlights the recent advances in NK cell (and ILC) research in human and mouse from basic research to clinical applications.

Tailoring NK Cell Receptor-Ligand Interactions: an Art in Evolution, 2nd Edition
  • Language: en
  • Pages: 407

Tailoring NK Cell Receptor-Ligand Interactions: an Art in Evolution, 2nd Edition

Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the un...

Tumor Immunology and Immunotherapy - Cellular Methods
  • Language: en
  • Pages: 554

Tumor Immunology and Immunotherapy - Cellular Methods

Tumor Immunology and Immunotherapy - Cellular Methods Part A, Volume 631, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters include Detection of intracellular cytokine production by T cells with flow cytometry, High-throughput identification of human antigen-specific CD8+ and CD4+ T cells using soluble pMHC multimers, In vitro assays for effector T cell functions and activity of immunostimulatory antibodies, Ex vivo energetic profiling of tumor cells and T cells from mouse models and human samples, A cytofluorimetric assay to evaluate T cell polyfunctionality, and much more. Contains the authority of authors who are leaders in their field Provides a comprehensive source on new methods and research in enzymology

Cancer Research
  • Language: en
  • Pages: 996

Cancer Research

  • Type: Book
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  • Published: 2007-06
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  • Publisher: Unknown

None

European Cytokine Network
  • Language: en
  • Pages: 582

European Cytokine Network

  • Type: Book
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  • Published: 1999
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  • Publisher: Unknown

None

Emerging Engineering Approaches in Cancer Immunotherapy
  • Language: en
  • Pages: 205

Emerging Engineering Approaches in Cancer Immunotherapy

None

Caractérisation immunologique et enzymatique des phagocytes mononucléés chez l'homme et chez le rat
  • Language: fr
  • Pages: 93