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Stem Cells
The main objective of this book is to present a thorough update on stem cell research and the potential therapeutic applications of stem cells. The text is structured following a path that starts from the molecular basics and the biological properties of pluripotent, embryonic or reprogrammed stem cells, and it compares the different degrees of stemness, while describing the adult stem populations residing in the various tissues and organs of the human body. Starting from basic research, the book discusses examples of regenerative medicine that translate the experimental findings into clinical applications of cell therapy. Finally, the book reviews how stem cells represent a model to understand not only the physiological mechanisms that control their fate, but also the pathological mechanisms involved in the aberrant biology of cancer stem cells. Each chapter has been conceived by distinguished researchers in the field who provide detailed and updated contributions that distill knowledge in a very readable text.
Circular RNAs
This book provides an essential overview of the rapidly advancing field of circular RNAs – newly discovered RNAs that are generated by back-splicing precursor mRNA and perform regulatory functions in many biological processes. Although many aspects of circular RNAs’ biology and mechanisms of gene regulation remain unclear, they have been found to be abundant, evolutionally conserved, and stable in cells; further, they have numerous potential functions. The book consists of eight parts:1) An overview of circular RNAs, 2) Bioinformatics for circular RNAs, 3) Biogenesis of circular RNAs, 4) Molecular mechanisms and gene regulation of circular RNAs, 5) Circular RNAs as potential disease biomarkers, 6) Circular RNAs and human diseases, 7) Circular RNAs in Plants and in Archaea, and 8) Future prospects. Given its focus, the book will be especially useful for researchers and students in the fields of biochemistry, molecular biology, cell biology, and medicine.
From Old English to Standard English
"This practical and informative course book is a fascinating, visual volume which leads the student through the development of the language from Old English, through Middle and Early Modern English to the establishment of Standard English in the eighteenth century." "At the core of this substantially expanded second edition lies a series of nearly 200 historical texts, of which more than half are reproduced in facsimile, and which illustrate the progressive changes in the language. The book is firmly based upon linguistic description, with commentaries which form a series of case studies demonstrating the evidence for language change at every level - handwriting, spelling, punctuation, vocabulary, grammar and meaning." "Such a wealth of texts, as well as the structured activities and the various case studies, allow the volume to be used not only as a stimulating course text, guiding students through the analysis of data, but also as a comprehensive resource book and invaluable reference tool for teachers and students at all levels."--BOOK JACKET.Title Summary field provided by Blackwell North America, Inc. All Rights Reserved
The Human Placenta
The placenta is fascinating and complex. Basically foreign to the maternal body, it can be thought of as an organ transplanted onto the mother's host tissue. As such it embodies all the principles of tissue acceptance and rejection. Many of the risks of pregnancy and labor have now been eliminated and the placenta is likely to be at the root of many of the dangers to the unborn child that remain. A breakdown of the relationship between the placenta and the maternal tissue may turn out to be the cause of the majority of early lost pregnancies.
