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The Jews in Sicily
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The Jews in Sicily, Volume 10 Notaries of Palermo
This volume of the Documentary History of the Jews in Italy is the second of the second series, illustrating the history of the Jews in Sicily based on notarial and court records. It is the sequel to the eight volumes of the first series. Notarial deeds drawn up by public notaries in Palermo and elsewhere and cases brought before the Pretorian Court in Palermo present a kaleidoscopic picture of the private lives of the Jews of Sicily during the last three centuries of their presence on the island. They illustrate the economic, social and religious history of the Jewish minority and the relations with the Christian majority. Much information is provided on trade and commerce, crafts and profe...
Northumberland Legal Journal
Contains opinions of cases decided in the Eighth and Seventeenth judicial districts of Pennsylvania, comprising the counties of Northumberland, Union and Snyder (varies slightly).
Sicilian Visitors Volume 2 - Culture
Sicilian Visitors Vol 2 - Culture focuses on a wide range of cultural aspects of the island of Sicily including religion, literature, art, music, science, sports, food as well describing visitors who have come to the island and their impressions. Vol.2 is the companion of Vol 1 which describes the island ́s history.
Construction and utilization of digital twins for personalized therapeutic predictions
Modern healthcare faces a significant challenge, namely that 25-70% of patients with common diseases do not benefit from standard treatments despite the availability of over 13,000 drugs registered in DrugBank. This discrepancy is likely due to these diseases' complex and heterogeneous molecular nature rather than a lack of therapeutic options. Emerging technologies have revealed the immense molecular complexity underlying common diseases. For instance, singlecell RNA sequencing (scRNA-seq) has demonstrated altered gene interactions in and across multiple cell types in numerous tissues. Furthermore, these technologies have revealed vast molecular differences between patients with the same di...
Effects of Pregnancy and Hormones on T cell Immune Regulation in Multiple Sclerosis
Multiple sclerosis (MS) is characterized by a dysregulated immune system leading to chronic inflammation in the central nervous system. Despite increasing number of treatments, many patients continue to deteriorate. A better understanding of the underlying disease mechanisms involved in driving disease is a pre-requisite for finding new biomarkers and new treatment targets. The improvement of MS during pregnancy, comparable to the beneficial effects of the most effective treatment, suggests that the transient and physiological immune tolerance established during pregnancy could serve as a model for successful immune regulation. Most likely the immune-endocrine alterations that take place dur...
The Vision Zero Petition
In the aftermath of losing our two youngest daughters, AnnaLeah (17) and Mary (13), due to a truck underride crash on May 4, 2013, we became aware of far too many facts about tra ffic fatalities. In an e ffort to do more than just put a bandaid on the problem, we launched a campaign to call for major change in how safety laws and regulations are determined. Th€is book is a compilation of our request for a National Vision Zero Goal and for a Vision Zero rulemaking policy. It includes our petition letters to President Obama and DOT Secretary Foxx--along with the signatures and comments of thousands of people who signed the petitions and are speaking up with us to call for a move Towards Zero Crash Deaths & Serious Injuries.
Identification of genes and regulators that are shared across T cell associated diseases
Genome-wide association studies (GWASs) of hundreds of diseases and millions of patients have led to the identification of genes that are associated with more than one disease. The aims of this PhD thesis were to a) identify a group of genes important in multiple diseases (shared disease genes), b) identify shared up-stream disease regulators, and c) determine how the same genes can be involved in the pathogenesis of different diseases. These aims have been tested on CD4+ T cells because they express the T helper cell differentiation pathway, which was the most enriched pathway in analyses of all disease associated genes identified with GWASs. Combining information about known gene-gene inte...
Sex differences in atherosclerosis and exercise effects
Cardiovascular disease (CVD) is the leading cause of death globally, with atherosclerosis being the main cause of cardiovascular diseases. Atherosclerosis is an inflammatory disease of the blood vessel wall, which over time will cause thickening and hardening of the vessel wall. Atherosclerosis can result in catastrophic vascular events, such as myocardial infarction and stroke. There are distinct sex differences in CVD mortality at different ages, before menopause women have a lower mortality of CVD in comparison to men, which equalises after menopause. In addition to sex differences in the incidence of CVD, there are also distinct sex differences in the phenotype of atherosclerotic plaques...
