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Biomolecular Interfaces
The book focuses on the aqueous interface of biomolecules, a vital yet overlooked area of biophysical research. Most biological phenomena cannot be fully understood at the molecular level without considering interfacial behavior. The author presents conceptual advances in molecular biophysics that herald the advent of a new discipline, epistructural biology, centered on the interactions of water and bio molecular structures across the interface. The author introduces powerful theoretical and computational resources in order to address fundamental topics such as protein folding, the physico-chemical basis of enzyme catalysis and protein associations. On the basis of this information, a multi-disciplinary approach is used to engineer therapeutic drugs and to allow substantive advances in targeted molecular medicine. This book will be of interest to scientists, students and practitioners in the fields of chemistry, biophysics and biomedical engineering.
Transformative Concepts for Drug Design: Target Wrapping
In spite of the enticing promises of the post-genomic era, the pharmaceutical world is in a state of disarray. Drug discovery seems now riskier and more uncertain than ever. Thus, projects get routinely terminated in mid-stage clinical trials, new targets are getting harder to find, and successful therapeutic agents are often recalled as unanticipated side effects are discovered. Exploiting the huge output of genomic studies to make safer drugs has proven to be much more difficult than anticipated. More than ever, the lead in the pharmaceutical industry depends on the ability to harness innovative research, and this type of innovation can only come from one source: fundamental knowledge. Thi...
Last Dance in Havana
In power for forty-four years and counting, Fidel Castro has done everything possible to define Cuba to the world and to itself -- yet not even he has been able to control the thoughts and dreams of his people. Those thoughts and dreams are the basis for what may become a post-Castro Cuba. To more fully understand the future of America's near neighbor, veteran reporter Eugene Robinson knew exactly where to look -- or rather, to listen. In this provocative work, Robinson takes us on a sweaty, pulsating, and lyrical tour of a country on the verge of revolution, using its musicians as a window into its present and future. Music is the mother's milk of Cuban culture. Cubans express their fondest...
A Mathematical Approach to Protein Biophysics
This book explores quantitative aspects of protein biophysics and attempts to delineate certain rules of molecular behavior that make atomic scale objects behave in a digital way. This book will help readers to understand how certain biological systems involving proteins function as digital information systems despite the fact that underlying processes are analog in nature. The in-depth explanation of proteins from a quantitative point of view and the variety of level of exercises (including physical experiments) at the end of each chapter will appeal to graduate and senior undergraduate students in mathematics, computer science, mechanical engineering, and physics, wanting to learn about th...
Revisiting the Colonial Question in Latin America
From the configuration of Empire in the colonial period to the multiple facets of modern coloniality, this book offers a challenging approach to the developments and effects of imperial domination and neocolonial rule in Latin American.
AI
Delving into the deeply enigmatic nature of Artificial Intelligence (AI), AI: Unexplainable, Unpredictable, Uncontrollable explores the various reasons why the field is so challenging. Written by one of the founders of the field of AI safety, this book addresses some of the most fascinating questions facing humanity, including the nature of intelligence, consciousness, values and knowledge. Moving from a broad introduction to the core problems, such as the unpredictability of AI outcomes or the difficulty in explaining AI decisions, this book arrives at more complex questions of ownership and control, conducting an in-depth analysis of potential hazards and unintentional consequences. The bo...
An Introduction to Universal Artificial Intelligence
An Introduction to Universal Artificial Intelligence provides the formal underpinning of what it means for an agent to act intelligently in an unknown environment. First presented in Universal Algorithmic Intelligence (Hutter, 2000), UAI offers a framework in which virtually all AI problems can be formulated, and a theory of how to solve them. UAI unifies ideas from sequential decision theory, Bayesian inference, and algorithmic information theory to construct AIXI, an optimal reinforcement learning agent that learns to act optimally in unknown environments. AIXI is the theoretical gold standard for intelligent behavior. The book covers both the theoretical and practical aspects of UAI. Baye...
Transcending Imagination
Imagine a world where the boundaries of creativity are not only stretched but redefined. This book serves as your guide to this new frontier, engaging general readers, tech enthusiasts, and creatives alike in the captivating interplay between human ingenuity and artificial intelligence (AI). Journey through the ground-breaking advancements in AI as they intersect with art, design, entertainment, and education. Discover how AI’s power to analyze and understand language can be harnessed to generate breathtaking visuals from mere text descriptions—a process known as text-conditional image generation. But this book goes beyond just showcasing AI’s capabilities: it delves into its transform...
Human-Centered AI
Artificial intelligence (AI) permeates our lives in a growing number of ways. Relying solely on traditional, technology-driven approaches won't suffice to develop and deploy that technology in a way that truly enhances human experience. A new concept is desperately needed to reach that goal. That concept is Human-Centered AI (HCAI). With 29 captivating chapters, this book delves deep into the realm of HCAI. In Section I, it demystifies HCAI, exploring cutting-edge trends and approaches in its study, including the moral landscape of Large Language Models. Section II looks at how HCAI is viewed in different institutions—like the justice system, health system, and higher education—and how i...
Cuba Represent!
In Cuba something curious has happened over the past fifteen years. The government has allowed vocal criticism of its policies to be expressed within the arts. Filmmakers, rappers, and visual and performance artists have addressed sensitive issues including bureaucracy, racial and gender discrimination, emigration, and alienation. How can this vibrant body of work be reconciled with the standard representations of a repressive, authoritarian cultural apparatus? In Cuba Represent! Sujatha Fernandes—a scholar and musician who has performed in Cuba—answers that question. Combining textual analyses of films, rap songs, and visual artworks; ethnographic material collected in Cuba; and insight...
