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Circuit Mechanisms of Neurodegenerative Diseases
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Neuroimaging in Schizophrenia
This comprehensive book explains the importance of imaging techniques in exploring and understanding the role of brain abnormalities in schizophrenia. The findings obtained using individual imaging modalities and their biological interpretation are reviewed in detail, and updates are provided on methodology, testable hypotheses, limitations, and new directions for research. The coverage also includes important recent applications of neuroimaging to schizophrenia, for example in relation to non-pharmacological interventions, brain development, genetics, and prediction of treatment response and outcome. Written by world renowned experts in the field, the book will be invaluable to all who wish to learn about the newest and most important developments in neuroimaging research in schizophrenia, how these developments relate to the last 30 years of research, and how they can be leveraged to bring us closer to a cure for this devastating disorder. Neuroimaging in Schizophrenia will assist clinicians in navigating what is an extremely complex field and will be a source of insight and stimulation for researchers.
SOBP 2015 Abstracts
None
Data Driven Science for Clinically Actionable Knowledge in Diseases
Data-driven science has become a major decision-making aid for the diagnosis and treatment of disease. Computational and visual analytics enables effective exploration and sense making of large and complex data through the deployment of appropriate data science methods, meaningful visualisation and human-information interaction. This edited volume covers state-of-the-art theory, method, models, design, evaluation and applications in computational and visual analytics in desktop, mobile and immersive environments for analysing biomedical and health data. The book is focused on data-driven integral analysis, including computational methods and visual analytics practices and solutions for discovering actionable knowledge in support of clinical actions in real environments. By studying how data and visual analytics have been implemented into the healthcare domain, the book demonstrates how analytics influences the domain through improving decision making, specifying diagnostics, selecting the best treatments and generating clinical certainty.
Brain Function and Dysfunction
Alzheimer's Disease is rapidly increasing in prevalence. This pandemic of the post-industrial age wreaks havoc on the elderly people (some as young as 40), particularly in the richer and more powerful nations. With only a few weak hypotheses, its cause is not understood; all proposed medicines have either failed clinical trials or proven ineffective. In this book, I lay out a new, relatively stronger and more broad-based theory of dementia causation, exploring beyond Matsuyama's 1989 theory that held pervasive Microtubule collapse to be a key characteristic of dementia. In brief: Psychological functions are carried out by neurocircuits containing myriads of Dopaminergic and Norepic systems; due to excessive electrical signalling in "dopamine-heavy" types of brains -- the signal conducting micro-tubules break down, causing the neuronal collapse which characterizes dementia. More the signalling volume, more the stress (either mechanical and/or thermal and/or chemical stress), which proves fatal in the end.
A Profession Without Reason
There is today a crisis in psychiatry. Even the former director of the National Institute of Mental Health, Thomas Insel, has said: “Whatever we’ve been doing for five decades, it ain’t working.” The field requires a completely fresh look, and clinical psychologist Bruce Levine—a man often at odds with his profession—enlists the early Enlightenment philosopher Baruch de Spinoza to help work through the problem. Readers unfamiliar with Spinoza will be intrigued by the modern relevance of his radical philosophical, psychological, and political ideas. Levine compares the radical/moderate divide among Enlightenment thinkers to a similar divergence between contemporary critics of psychiatry, siding historically with Spinoza in order to bring an equivalent intellectual force to bear upon our modern crisis and calling for new forms of free and enlightened thinking.
Vom Mythos des Normalen
Eine neue Sicht auf Gesundheit * Spiegel BESTSELLER * * NEW YORK TIMES BESTSELLER * Wir neigen dazu zu glauben, dass Normalität mit Gesundheit gleichzusetzen ist. Doch was ist eigentlich die Norm in westlichen Gesellschaften? Dieser Frage geht der renommierte Experte, Arzt und Bestsellerautor Gabor Maté in seinem neuen Buch nach. Er hat eine umfassende Untersuchung der Ursachen von Krankheiten zusammengestellt, die vor allem zeigt, wie unsere Gesellschaft diese hervorbringt und begünstigt, und wie ein natürlicher Weg zu Gesundheit und Heilung aussehen kann. Gabor Maté macht deutlich, dass unser Verständnis dessen, was als gesundheitlich »normal« gilt, falsch ist, denn es vernachläss...
Early Brain Sprouts from States to Traits
Today, the society is at a crossroads, spending billions of dollars on fixing drug addiction problems, teen pregnancy, and youth health-risk behaviors and violence but unable to accomplish the goals. Prevalence of ADHD, spectrum behaviors, explosive temper, bipolar disorder, violence everywhere, teen anxiety and depression, and drug abuse problems are still high. NIH data shows that 40% of eighteen- to thirty-four-year-olds have some mental health issues that need help. Dollars are spent when changes cannot happen. If the same money is spent in educating general masses through the community organizations on the brain synaptic proliferation for zero- to three-year-olds in their optimal intell...
De mythe van normaal
In 'De mythe van normaal' laat Gabor Maté zien wat 'normaal' in een toxische maatschappij betekent voor trauma, ziekte en heling. In De mythe van normaal, over trauma, ziekte en heling in een toxische maatschappij ontleedt Gabor Maté de onderliggende oorzaken van onze fysieke en emotionele malaise, en legt hij verbanden tussen ons persoonlijk lijden en de druk van het jachtige bestaan. Wij zijn geneigd te geloven dat ‘normaal’ gelijk staat aan ‘gezond zijn’. Maar hoe gezond is die norm nu echt? Maté ontdekte dat de gangbare definitie van ‘normaal’ niet juist is: vrijwel alle ziekte is een natuurlijke weerspiegeling van het leven in een ongezonde samenleving, waarin gezondheids...
