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Viruses
Viruses encapsulates for the lay reader the enormous scientific and medical contributions that have come from the field of virology. Dr. Arnold Levine presents the story of the scientists behind our current understanding of these infective agents and explains how that knowledge has helped us comprehend life at both the molecular and the human level. Many intriguing facets of viral behavior are explored, as Dr. Levine provides a clear account of their natural history, the mechanisms by which they spread and survive, and the toll they exact on their animal, plant, and bacterial hosts. Dr. Levine celebrates the great successes that have come from viral studies--the development of a wide range o...
The P53 Protein
Decades of research on the tumor suppressor p53 have revealed that it plays a significant role as a "guardian of the genome," protecting cells against genotoxic stress. In recent years, p53 research has begun to move into the clinic in attempts to understand how p53 is frequently inactivated in-and sometimes even promotes-human cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the rapid progress that has recently been made in basic and clinical research on p53. The contributors review new observations about its basic biology, providing updates on the functions of its isoforms and domains, the myriad stresses and signal...
Current Catalog
First multi-year cumulation covers six years: 1965-70.
Secrets by the Bay
A true crime story. An unsolved mystery about Sabrina Paige Aisenberg.
Aerosmith
None
Murder in the Tropics
Here is the first statewide collection of true Florida murders, and, as the saying goes, truth is stranger than fiction. The Sunshine State has played host to a memorable and varied array of crimes of passion, greed, and revenge. In stories spanning from the 1860s to the 1990s, you will meet such varied characters as Lena Clarke, a killer with both her feet planted in a dozen bewildering worlds; Terry Jo, the Sea Waif; Chief Tigertail; the outlaw Ed Watson; Blue, the Enforcer; President Franklin Roosevelt; the Duke of Windsor; novelist Zora Neale Hurston; Lobster Boy; the Gulf Stream Pirate; Brother Gillette, a gentle Shaker who killed out of compassion; and Pensacola's Black Widow, a Spider Woman who killed without mercy. Next in series > > See all of the books in this series
The p53 Tumor Suppressor Pathway and Cancer
The current year (2004) marks the Silver Anniversary of the discovery of the p53 tumor suppressor. The emerging ?eld ?rst considered p53 as a viral antigen and then as an oncogene that cooperates with activated ras in transforming primary cells in culture. Fueling the concept of p53 acting as a transforming factor, p53 expression was markedly elevated in various transformed and tumorigenic cell lines when compared to normal cells. In a simple twist of fate, most of the studies conducted in those early years inadvertently relied on a point mutant of p53 that had been cloned from a normal mouse genomic library. A bona ?de wild-type p53 cDNA was subsequently isolated, ironically, from a mouse t...
