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As Wings Unfurl
Applegate Bogdanski returns from Vietnam with a missing leg, a Purple Heart, and an addiction to morphine. He stumbles through each day, looking forward to nothing and hoping it will arrive soon. When he attempts to thwart a crime, he is knocked unconscious and wakes up to discover that people are once again calling him a hero, though he feels undeserving of the praise. Apple returns to work and meets Angela, a mysterious woman who claims to be his guardian. Immediately, he feels a connection to her, which morphs into an attraction. But he soon discovers that Angela is much more than she seems. Apple and Angela are swept up in a conspiracy that stretches through time and space. Together, they must fight to save everything they hold dear from an alien race bent on destroying humanity.
Algorithm
A gold medallion is discovered in a lump of coal over a hundred million years old. It contains a code describing human DNA at a time when there were no humans. How could this be? Adam Dove wants to know, but when he starts to investigate, his laboratory is destroyed and a close friend is murdered. Joined by a brilliant biochemist, Linda Garcia, the two are hunted by a Nazi underground bent on retrieving the disk and a mysterious alien presence, which may be more interested in destroying it. Adam and Linda face the most difficult decision of their lives-to leave all they know behind for the chance to discover mankind's origin and purpose.
Drug Design
This book provides a complete snapshot of various experimental approaches to structure-based and ligand-based drug design and is illustrated with more than 200 images.
Drug Design
Structure-based (SBDD) and ligand-based (LBDD) drug design are extremely important and active areas of research in both the academic and commercial realms. This book provides a complete snapshot of the field of computer-aided drug design and associated experimental approaches. Topics covered include X-ray crystallography, NMR, fragment-based drug design, free energy methods, docking and scoring, linear-scaling quantum calculations, QSAR, pharmacophore methods, computational ADME-Tox, and drug discovery case studies. A variety of authors from academic and commercial institutions all over the world have contributed to this book, which is illustrated with more than 200 images. This is the only book to cover the subject of structure and ligand-based drug design, and it provides the most up-to-date information on a wide range of topics for the practising computational chemist, medicinal chemist, or structural biologist. Professor Kenneth Merz has been selected as the recipient of the 2010 ACS Award for Computers in Chemical & Pharmaceutical Research that recognizes the advances he has made in the use of quantum mechanics to solve biological and drug discovery problems.
All the Lovely Children
Charly Bloom’s life took a wrong turn that has left her alone and frustrated. When she gets a call from an old flame, she returns to her hometown to investigate the disappearances of four children. The abductions are eerily similar to a set of previous crimes. Two decades ago, Charly and her three friends decided to play amateur detectives and help find a girl who was stolen from her home. Then, another girl went missing. Clues overlooked by the inept sheriff left only one child to survive: Charly. She managed to fight back and kill the Snatcher. Or so everyone thought… Is the Snatcher back, or is there a copycat? Charly must face her past and her own personal demons in a race against time to save the latest victim.
Contact
A cast of authors from past, present and future make up this collection of eighteen stories featuring original works and classic reprints. Contact: Stories of the New World takes you beyond the edge of the solar system into the uncharted horizons of deep space, where the spaces and dimensions in between are explored and worlds of mystery are discovered. New beginnings. Old fears. Persistence of vision. Here are the chronicles of the new world. Arthur Doweyko, August Derleth, Cassandra Arnold, Chris Limb, Clint Wastling, Damien Krsteski, Frederic Brown, HG Wells, Jason Andrew, Kurt Heinrich Hyat, Margaret Karmazin, Margaret Pearce, Neil R Jones, Philip K Dick, Poul Anderson, Scathe meic Beorh...
Reviews in Computational Chemistry, Volume 11
Volume 11 Reviews in Computational Chemistry Kenny B. Lipkowitz and Donald B. Boyd The Theme of this Eleventh Volume is Computer-Aided Ligand Design and Modeling of Biomolecules. A Stellar Group of Scientists from Around the World Join in this Volume to Provide Tutorials for Beginners and Experts. Chapters 1 and 2 Take A Detailed Look at De Novo Design Methodologies for Discovering New Ligands which May Become Pharmaceuticals. Chapters 3 and 4 Cover the Methods and Applications of Three-Dimensional Quantitative Structure-Activity Relationships (3D-QSAR) Currently Used in Drug Discovery. Ways to Compute the Correct Lipophilic/Hydrophilic Behavior of Molecules are Taught in Chapter 5. Chapter ...
Molecular Modeling and Prediction of Bioactivity
Much of chemistry, molecular biology, and drug design, are centered around the relationships between chemical structure and measured properties of compounds and polymers, such as viscosity, acidity, solubility, toxicity, enzyme binding, and membrane penetration. For any set of compounds, these relationships are by necessity complicated, particularly when the properties are of biological nature. To investigate and utilize such complicated relationships, henceforth abbreviated SAR for structure-activity relationships, and QSAR for quantitative SAR, we need a description of the variation in chemical structure of relevant compounds and biological targets, good measures of the biological properti...
Intraterrestrial
Adam Helios is a bully magnet without many friends. When he starts hearing a voice that claims to come from the stars, he fears he’s losing his mind, so he withdraws even further. On the way home from a meeting at the school, he and his parents are involved in a horrible car crash. With his skull cracked open, Adam’s consciousness is abducted by the alien who has been speaking to him for months. After surviving the wreck with only minor scratches, Camille Helios must deal with her guilt over the accident that left her husband badly injured and her son in a coma. When the doctor suggests letting Adam go, Camille refuses to stop fighting for her son’s life. Lost among galaxies, Adam must use his imagination to forge a path home before his body dies on the operating table. But even if he does return to Earth, he may end up locked inside a damaged brain forever.
