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Advances in the Treatment of Hormonal Receptor positive (HR+) Breast Cancer
Breast cancer is the most common cancer in women. Breast cancer subtypes are classified according to histologic features, including morphology and receptor status. Information on the expression of estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor 2 (HER2), as well as the proliferation index Ki67 (in early-stage disease), are relevant for clinical decisions. Molecular tests are now available to further classify the disease into subgroups, stratify risk or estimate the benefit of interventions. Some examples of such tests include the Recurrence Score (OncotypeDX), PAM50 (Prosigna), Mammaprint, Blueprint, and Breast Cancer Index (BCI), among others.
Retinal Degenerative Diseases
Retinal Degenerations is the result of the International Symposium on Retinal degeneration which has become perhaps the most important research meeting in the field. THe topics in this volume explore the etiology, cellular mechanisms, epidemiology, genetics, models and potential therapeutic measures for the blinding diseases of retinitis pigmentosa and age-related macular degeneration.
AACR 2016: Abstracts 2697-5293
The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.
Fashion Statements
While there have been scholarly commentaries on the philosophy of fashion, none yet have attempted to engage fashion on its own hybrid, inflected, and heterogeneous terms. Celebrating the plurality and audacity inherent in its subject, Fashion Statements presents insightful, playful, and accessible essays on the philosophy of fashion.
Cancer Cell Chemoresistance And Chemosensitization
Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chemo...
Art in the Age of Technoscience
Art, the Life Sciences, and the Humanities: In Search ofa Relationship Robert Ztuijnenberg Over the last decades there has been a distinctive effort in the arts to engage with science through participation in the actual practice of science. ' Exchange proj ects between artists and scientists, such as artist-in-lab projects, have become common and a large number oforganizations have emerged that stimulate and initiate collaboration between artists andscientists. ' Research funding organiza tions in thehumanities,such asthe British Arts and Humanities Research Coun cil (AHRC) and the Netherlands Organisation for Scientific Research (NWO), have also initiated all sorts of research programs that...
Apoptosis in Health and Disease - Part A
Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. A vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target this cell death process. These two thematic volumes 125 and 126 of the Advances in Protein Chemistry and Structural Biology focus on apoptotic responses in numerous conditions - from bacterial and parasite infections to pathological states such as oxidative stress, pulmonary hypertension, different cancer types, etc. Finally, therapeutic strategies for targeting apoptosis are also discussed. - Integrates experimental and computational methods for studying apoptosis in health and different diseases, strategies for identification of suitable therapeutic targets, and design of treatments targeting key points in apoptotic cascade
Dialogues Between Artistic Research and Science and Technology Studies
This edited volume maps dialogues between science and technology studies research on the arts and the emerging field of artistic research. The main themes in the book are an advanced understanding of discursivity and reasoning in arts-based research, the methodological relevance of material practices and things, and innovative ways of connecting, staging, and publishing research in art and academia. This book touches on topics including studies of artistic practices; reflexive practitioners at the boundaries between the arts, science, and technology; non-propositional forms of reasoning; unconventional (arts-based) research methods and enhanced modes of presentation and publication.
