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Stem Cells and Their Potential for Clinical Application
The NATO-ASI conference Stem Cells and Their Potential for Clinical Application featured cutting-edge presentations ranging from laboratory research findings to the latest therapeutic applications. This book features contributions from many of the leading international scientists from North America and Western and Eastern Europe who participated in this conference. Articles cover a broad range of hot topics in stem cell and leukemia research.
Gene Technology
The 11 th meeting in "Modern Trends in Human Leukemia" took place from June 19 to 21, 1994 in Wilsede in the middle of the Liineburger Heide, South of Hamburg. Interwoven with the Leukemia program was the Nato-sponsored Symposium of the ASI-Series "Gene Technology in Analysis of Malignant and Inherited Human Diseases Related to Development" . The Wilsede meeting was continued on a ship of the Neva leading through lake Ladoga and lake Onega. The topics of both meetings included discussion on recent progress isolation and development of hematopoietic stem cells, genes crucial for development and diseases, methods of gene transfer, application of gene transfer; oncogenes and anti-oncogenes as t...
Stem Cells and Cancer Stem Cells,Volume 3
It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Bec...
Lithium Effects on Granulopoiesis and Immune Function
This monograph contains papers which resulted from an international workshop on the effects of lithium on the hematopoietic and immunologic systems. The meeting was held at the John L. and Beatrice Keeshin International Biomedical Systems Planning Center of Rush University in Eagle River, Wisconsin from June 6 through June 9, 1979. The object of this conference was to bring together scientists from around the world with an interest in the effects of lithium and its potential use in human disease to bolster and stimulate the hematologic and immune systems. These topics seemed to us to be important and the time seemed right for bringing together the workers in these fields to exchange ideas an...
Gene Therapy of Cancer
The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.
Autologous Bone Marrow Transplantation for Hodgkin's Disease, Non-Hodgkin's Lymphoma and Multiple Myeloma
The book deals with the evaluation of high-dose chemotherapy followed by autologous bone marrow or blood stem cell trans- plantation as treatment forHodgkin's disease, non-Hodgkin's lymphoma and multiple myeloma. Alternative salvages strate- gies in this rapidly developing field are reviewed and risk factors associated with clinical outcome of newly diagnosed lymphomas and lymphomas in relapse are evaluated. Several fundamental issues like detection of minimal residual disease inbone marrow and blood, the need for bone marrow purging and preferences of blood stem cells to bone marrow are discussed. The use of hematopoietic growth factors such as GCSF and GMCSF after bone marrow transplantation are described.
Stem Cell Research
Embryonic stem cells have the ability to develop into virtually any cell in the body, and may have the potential to treat medical conditions such as diabetes and Parkinson's disease. In August 2001, President Bush announced that for the first time federal funds would be used to support research on human embryonic stem cells, but funding would be limited to 'existing stem cell lines'. The National Institutes of Health (NIH) has established the Human Embryonic Stem Cell Registry which lists stem cell lines that are eligible for use in federally funded research. Although 78 cell lines are listed, 21 embryonic stem cell lines are currently available. Scientists are concerned about the quality, l...
