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The NATO-ASI conference Stem Cells and Their Potential for Clinical Application featured cutting-edge presentations ranging from laboratory research findings to the latest therapeutic applications. This book features contributions from many of the leading international scientists from North America and Western and Eastern Europe who participated in this conference. Articles cover a broad range of hot topics in stem cell and leukemia research.
It is pointed out that cancer stem cell is a cell type within a tumor that possesses the capacity of cell-renewal and can give rise to the heterogeneous lineages of cancer cells that comprise the tumor. It is emphasized that a cancer stem cell is a tumor initiating cell. That conventional chemotherapy kills most cells in a tumor, but cancer stem cells remain intact is discussed. Vast applications of stem cells, cancer stem cells, mesenchymal stem cells, and human pluripotent stem cells are discussed. Because human embryonic stem cells possess the potential of producing unlimited quantities of any human cell type, considerable focus is placed on their therapeutic potential in this volume. Bec...
The book provides a comprehensive overview of the current state, and the new concepts for the future directions of modern cancer therapy. Bringing together all the relevant aspects from basic and applied science, and the clinical experiences of this new direction in medicine, it is an up-to-date summary of the activities in the field and will be the basis for evaluating future progress in this area.
The book deals with the evaluation of high-dose chemotherapy followed by autologous bone marrow or blood stem cell trans- plantation as treatment forHodgkin's disease, non-Hodgkin's lymphoma and multiple myeloma. Alternative salvages strate- gies in this rapidly developing field are reviewed and risk factors associated with clinical outcome of newly diagnosed lymphomas and lymphomas in relapse are evaluated. Several fundamental issues like detection of minimal residual disease inbone marrow and blood, the need for bone marrow purging and preferences of blood stem cells to bone marrow are discussed. The use of hematopoietic growth factors such as GCSF and GMCSF after bone marrow transplantation are described.
This monograph contains papers which resulted from an international workshop on the effects of lithium on the hematopoietic and immunologic systems. The meeting was held at the John L. and Beatrice Keeshin International Biomedical Systems Planning Center of Rush University in Eagle River, Wisconsin from June 6 through June 9, 1979. The object of this conference was to bring together scientists from around the world with an interest in the effects of lithium and its potential use in human disease to bolster and stimulate the hematologic and immune systems. These topics seemed to us to be important and the time seemed right for bringing together the workers in these fields to exchange ideas an...
First multi-year cumulation covers six years: 1965-70.