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Starting with discussion of basic concepts and the molecular mechanisms of necrosis, this book looks first at several forms of necrotic cell death that have been identified, including necroptosis, autophagic cell death, and PARP-mediated cell death. As necrotic cell death is increasingly known to play a critical role in many physiological processes, the next chapters discuss its effect on metabolism, inflammation, immunity, and development. Necrotic cell death is closely implicated in human diseases like cancer, so the next chapters examine its relevance to human diseases, and final chapters cover methodologies for measuring necrosis. This book presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.
JIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
This book establishes, and then analyses, the interrelation between series and dependence by focusing on two aspects of their connection: the overconsumption of TV series, and the production devices that lead to it. Due to its two-sided nature, the volume brings together specialists from different backgrounds. On the one hand, it involves people working with addiction, such as psychiatrists, psychologists, and social workers, whose analytical tools and statistics are extremely useful in assessing the prevalence of TV series addiction, as well as its consequences, in order to make sense of its mechanics. For similar reasons, the authors also include professionals working with children and tee...
The Heart Has Its Reasons explores a hitherto neglected area of theological anthropology: the unity of human emotion and reason embodied in the Biblical concept of the heart. While the theological contours of human rationality have long been clearlydrawn and presented as the exclusive seat of the image of God, affectivity has been relegated to a secondary position. With the reintegration of the body into recent philosophical and theological discourses, a number of questions have arisen: if theimage (also) resides in the body, how does this change one's view of the theological significance of human affect? In what way is our likeness to God realised in the whole of what we are? Can one overcome the traditional dissociation between intellect and affect by a renewed theory of love? In conversation with patristic and medieval authors like Irenaeus, Tertullian, Gregory of Nyssa, Maximus, and Thomas Aquinas, and in dialogue with more recent interlocutors such as Blaise Pascal, Ricoeur, Marion, Milbank, and John Paul II, Beata Toth pursues a novel theological vision of the essential unity of our humanity.
Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers research methods in biomineralization science - Regulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches
This book employs the methods of philosophical anthropology to examine the question of what the noumenon of human life is which has been debated for thousands of years. This work elaborates upon the noumenon of human life, that is, man’s “structure and choice”. The noumenon of human life differs essentially from the animals in bringing about the unity of “structure” and “choice”. The noumenon of human life, or rather, man’s “structure and choice”, provides the motive force for the survival and development of individuals and groups (families, organizations and states) as well as the basic ways in which human values can be possible of realization. It is only through the ins...
It has been over 200 years since Fusarium pathogens were described for the first time, and they are still in the spotlight of researchers worldwide, mostly due to the mycotoxigenic abilities and the subsequent introduction of harmful metabolites into the food chain. The accelerating climatic changes are resulting in pathogen population and chemotype shifts all around the world, thus increasing the demand for continuous studies of factors that affect the virulence, disease severity and mycotoxin accumulation in plant tissues. This Special Issue summarizes recent advances in the field of Fusarium genetics, biology and toxicology.