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Biotechnology and the Human Genome
This book is based on the proceedings of the Science Writers Workshop on "Biotechnology and the Human Genome: Innovations and Impacts" held at the Brookhaven National Laboratory on September 14-16, 1987. The aim of this workshop which was sponsored by the Office of Health and Environmental Research of the Department of Energy (DOE) was to provide a forum in which science writers, reporters and other interested individuals could gain a firsthand knowledge about the scope and direction of the human genome initi ative and its supportive technologies. The speakers were leaders working in scientific disciplines that are either integral parts of the Department's genome project or that represent im...
From Biotechnology To Genomes: The Meaning Of The Double Helix
Aimed at scientists and non-specialised readers alike, this book retraces the source of national and international biotechnology programmes by examining the origins of biotechnology and its political and economic interpretation by large nations. With a foreword by André Goffeau, who initiated the European Yeast Genome Project, the book describes the achievements of the first genetic and physical maps, as well as the political and scientific genesis of the American Human Genome Project. Following these advances, the author discusses the European biotechnology strategy, the birth and implementation of European biotechnology programmes and the yeast genome project. After a detailed description...
Antimutagenesis and Anticarcinogenesis Mechanisms II
The papers are arranged in eight sections, addressing: antimutagens in food; antimutagens and anticarcinogens in environmental toxicology; free radicals; antitumor initiators; antitumor promoters; aspects of mammalian and human genetics; molecular aspects of mutagenesis and antimutageneis; and oncog
Physical and Chemical Mechanisms in Molecular Radiation Biology
The fundamental understanding of the production of biological effects by ionizing radiation may well be one of the most important scientific objectives of mankind; such understanding could lead to the effective and safe utilization of the nuclear energy option. In addition, this knowledge will be of immense value in such diverse fields as radiation therapy and diagnosis and in the space program. To achieve the above stated objective, the U. S. Department of Energy (DOE) and its predecessors embarked upon a fundamental interdisciplinary research program some 35 years ago. A critical component of this program is the Radiological and Chemical Physics Program (RCPP). When the RCPP was establishe...
DNA Damage and Repair in Human Tissues
Physical and chemical agents in the environment damage the DNA of humans, and pose a major threat to human health today, and to the genetic integrity of human populations. Although studies on isolated DNA in vitro, on prokaryotes, on mammalian cells in culture, and on laboratory animals have provided essential background information, it is now possible to study DNA damage and repair in human tissues directly. New techniques of high sensitivity, especially those not requiring radioactive labeling have made possible quantitation of DNA damage and repair, as well as detection of residual, unrepaired DNA lesions . In recent years, several investigators have taken up the challenge of studying dam...
Minutes of Meeting
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Human Genome News
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Boundaries between Promotion and Progression during Carcinogenesis
The pUrpOSE! of this conference was not to define the two areas that are being bound, which might be a well nigh impossible proposition. Rather, its focus was to concentrate on the mechanistic similarities between promotion and progression. Are the areas involved within the boundaries a continuum? Are these two simultaneous processes? Or are some of the affected cells in the stage of promotion when at the same time others have undergone irreversi ble changes tha. t position them in the stage of progression? Or are these two stages the same thing, but called by different names? To explore such concepts we assembled investigators with various back grounds and asked them to specifically address...
Synchrotron Radiation in Structural Biology
The development of synchrotron radiation (SR) as a research tool was driven largely by the needs of materials scientists and solid-state physi cists. However, the availability of SR has extended significantly the capa bility of scientists who study biological structure with radiation. This volume contains some of the results reported at a symposium held at Brookhaven National Laboratory in May 1988 to discuss the application of synchrotron radiation to structural biology. We are grateful for financial support from the u. s. Department of Energy, the National Institutes of Health, Genentech, Inc., Blake Indus tries, Inc., Evans and Sutherland Co., The Upjohn Company, Eli Lilly and Company, En...
